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    dup double parked [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47121, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dupprovided by FlyBase
    Official Full Name
    double parkedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000996
    Locus tag
    Dmel_CG8171
    See related
    AllianceGenome:FB:FBgn0000996
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    19k; anon-WO0257455.31; cdt1; Cdt1; CDT1; cdt1/dup; CDT1/DUP; CG8171; Dmel\CG8171; Dup; DUP; DUP/CDT1; fs(2)51Fa; fs(2)ltoPA77; fs(2)PA77; l(2)51Ec; l(2)k03308
    Summary
    Predicted to enable DNA binding activity and DNA polymerase binding activity. Involved in DNA endoreduplication; DNA replication checkpoint signaling; and glial cell growth. Located in cytoplasm; nucleus; and replication fork. Is expressed in cuboidal/columnar epithelium; female germline stem cell; follicle cell; and optic neuroblast. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dup in Genome Data Viewer
    Location:
    51F11-51F11; 2-74 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15376619..15380988, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11264124..11268493, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene SR Protein Kinase Neighboring gene long non-coding RNA:CR45020 Neighboring gene Stac-like Neighboring gene Metchnikowin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective tracking of template DNA strands after induction of mitosis with unreplicated genomes (MUGs) in Drosophila S2 cells. Drpic D, et al. Chromosome Res, 2013 May. PMID 23681663
    2. Preferential re-replication of Drosophila heterochromatin in the absence of geminin. Ding Q, et al. PLoS Genet, 2010 Sep 9. PMID 20838463, Free PMC Article
    3. Cellular checkpoint mechanisms monitoring proper initiation of DNA replication. Machida YJ, et al. J Biol Chem, 2005 Feb 25. PMID 15591064
    4. Characterization of null and hypomorphic alleles of the Drosophila l(2)dtl/cdt2 gene: Larval lethality and male fertility. Sloan RS, et al. Fly (Austin), 2012 Jul-Sep. PMID 22722696
    5. Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase. Lee HO, et al. Mol Biol Cell, 2010 Nov 1. PMID 20826610, Free PMC Article

    See all (132) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. phosphorylation and degradation of Dup protein at G1/S requires cyclin E/CDK2
      Title: Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.
    2. In cycling cells, Dup destruction is coupled to DNA replication and that increased levels of Gem balance elevated Dup levels to prevent pre-replicative complex reformation when Dup degradation fails.
      Title: Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA polymerase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorion-containing eggshell formation HMP PubMed 
    involved_in eggshell chorion gene amplification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glial cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    double parked
    Names
    CG8171-PA
    CG8171-PB
    double park
    double-parked
    doubleparked
    dup-PA
    dup-PB
    female sterile(2)51Fa
    lethal(2)51Ec
    speckled

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15376619..15380988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080139.5 → NP_524878.1  double parked, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524878.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVY2
      Related
      FBpp0086519
      Conserved Domains (2) summary
      cd08767
      Location:610 → 735
      Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase
      pfam08839
      Location:318 → 500
      CDT1; DNA replication factor CDT1 like

    2. NM_001299522.1 → NP_001286451.1  double parked, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286451.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVY2
      Conserved Domains (2) summary
      cd08767
      Location:610 → 735
      Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase
      pfam08839
      Location:318 → 500
      CDT1; DNA replication factor CDT1 like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JVY2 Q7JVY2

    Gene LinkOut

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