CG1620 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG1620provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0033183
Locus tag: Dmel_CG1620
See related: AllianceGenome:FB:FBgn0033183
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 146745_at; Dmel\CG1620
Summary: Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. Is expressed in several structures, including central brain primordium; dorsal ectoderm anlage; embryonic brain; posterior endoderm; and trunk mesoderm. Orthologous to several human genes including MIER1 (MIER1 transcriptional regulator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 43C5-43C6; 2-56 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7493806..7496466, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3381311..3383971, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG1620-PA; CG1620-PB; CG1620-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

7493806..7496466 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136443.3 → NP_610287.2 uncharacterized protein Dmel_CG1620, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610287.2

Status: REVIEWED

UniProtKB/TrEMBL

A1Z6Z7, D2NUG7

Related

FBpp0088056

Conserved Domains (3) summary

smart00717
Location:417 → 463

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:417 → 462

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:275 → 320

ELM2; ELM2 domain
NM_001273848.1 → NP_001260777.1 uncharacterized protein Dmel_CG1620, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260777.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z6Z7, D2NUG7

Conserved Domains (3) summary

smart00717
Location:417 → 463

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:417 → 462

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:275 → 320

ELM2; ELM2 domain
NM_001169601.2 → NP_001163072.1 uncharacterized protein Dmel_CG1620, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163072.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JGZ3, Q494K3

Conserved Domains (2) summary

pfam01448
Location:275 → 320

ELM2; ELM2 domain

cl21498
Location:417 → 450

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...