tj traffic jam [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tjprovided by FlyBase
Official Full Name: traffic jamprovided by FlyBase
Primary source: FLYBASE:FBgn0000964
Locus tag: Dmel_CG10034
See related: AllianceGenome:FB:FBgn0000964
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10034; DM13; Dmaf; Dmel\CG10034; fs(2)eo-B; fs(2)eo2; fs(2)eoPL3; maf-L; maf1; PL3; Tj; TJ
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including border follicle cell migration; gonad morphogenesis; and positive regulation of macromolecule biosynthetic process. Located in cytosol and nucleus. Is expressed in several structures, including adult brain; larval internal muscle motor neurons; somatic cell of ovariole; somatic cell of testis; and ventral nerve cord. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; eye disease (multiple); multicentric carpotarsal osteolysis syndrome; and type 2 diabetes mellitus. Orthologous to several human genes including MAF (MAF bZIP transcription factor); MAFA (MAF bZIP transcription factor A); and MAFB (MAF bZIP transcription factor B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 37E3-37E3; 2-54 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19464267..19467758)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19464267..19467758)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tissue-specific regulation of translational readthrough tunes functions of the traffic jam transcription factor.
Title: Tissue-specific regulation of translational readthrough tunes functions of the traffic jam transcription factor.
Traffic jam regulates the function of the ovarian germline stem cell progeny differentiation niche during pre-adult stage in Drosophila.
Title: Traffic jam regulates the function of the ovarian germline stem cell progeny differentiation niche during pre-adult stage in Drosophila.
Tj expression in the nerve cord interneurons.
Title: A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila.
Tj regulates the germline stem cell carrying capacity of the niche by controlling the fate and the spatial arrangement of niche cells.
Title: Specification and spatial arrangement of cells in the germline stem cell niche of the Drosophila ovary depend on the Maf transcription factor Traffic jam.
A branched pathway downstream of Notch in which Bowl functions to direct hub cell assembly in parallel to Tj downregulation, is reported.
Title: Traffic jam functions in a branched pathway from Notch activation to niche cell fate.
Data conclude that the regulatory feedback loop between Tj and Slbo is necessary for achieving the correct activity levels of migration-regulating factors to ensure proper BCC motility.
Title: The Maf factor Traffic jam both enables and inhibits collective cell migration in Drosophila oogenesis.
in gonadal somatic cells, tj gives rise simultaneously to two different molecules: the TJ protein, which activates Piwi expression, and piRNAs, which define the Piwi targets for silencing
Title: A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila.
role as critical modulator of the adhesive properties of somatic cells, facilitating germline-soma interactions that are essential for germ cell differentiation
Title: The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila.
Dmaf gene is expressed in somatic gonadal cells; results suggest a specific function for Dmaf in gonadal development, including migration and differentiation of primordial germ cells.
Title: Dmaf, a novel member of Maf transcription factor family is expressed in somatic gonadal cells during embryonic development and gametogenesis in Drosophila.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female gonad development	HMP more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	HMP more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: traffic jam

Names: CG10034-PB; CG10034-PC; Traffic-Jam; female sterile(2)eo2; tj-PB; tj-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

19464267..19467758

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273653.1 → NP_001260582.1 traffic jam, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260582.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PG80, Q7JS61

Conserved Domains (2) summary

cd14718
Location:419 → 486

bZIP_Maf_large; coiled coil [structural motif]

pfam03131
Location:397 → 486

bZIP_Maf; bZIP Maf transcription factor
NM_136125.3 → NP_609969.2 traffic jam, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609969.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7JS61, Q9VIW0

Conserved Domains (2) summary

cd14718
Location:419 → 486

bZIP_Maf_large; coiled coil [structural motif]

pfam03131
Location:397 → 486

bZIP_Maf; bZIP Maf transcription factor