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    Ttc19 Tetratricopeptide repeat domain 19 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35172, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttc19provided by FlyBase
    Official Full Name
    Tetratricopeptide repeat domain 19provided by FlyBase
    Primary source
    FLYBASE:FBgn0032744
    Locus tag
    Dmel_CG15173
    See related
    AllianceGenome:FB:FBgn0032744
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg15173; CG15173; Dmel\CG15173; dTTC19; TTC19
    Summary
    Involved in jump response; mitochondrial respiratory chain complex III assembly; and optomotor response. Located in mitochondrion. Is expressed in adult head; embryonic/larval midgut; and organism. Used to study mitochondrial complex III deficiency nuclear type 2. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 2. Orthologous to human TTC19 (tetratricopeptide repeat domain 19). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ttc19 in Genome Data Viewer
    Location:
    37B11-37B11; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19043535..19045148, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19043535..19045148, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene hook Neighboring gene uncharacterized protein Neighboring gene mind bomb 2 Neighboring gene Catecholamines up Neighboring gene Acinus Neighboring gene uncharacterized protein Neighboring gene lethal (2) 37Bb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction. Peruzzo R, et al. Nat Commun, 2021 Apr 8. PMID 33833234, Free PMC Article
    2. Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies. Ghezzi D, et al. Nat Genet, 2011 Mar. PMID 21278747
    3. Mitochondrial diseases: Drosophila melanogaster as a model to evaluate potential therapeutics. Foriel S, et al. Int J Biochem Cell Biol, 2015 Jun. PMID 25666557
    4. Mitochondrial Neurodegeneration: Lessons from Drosophila melanogaster Models. Brischigliaro M, et al. Biomolecules, 2023 Feb 16. PMID 36830747, Free PMC Article
    5. Transcriptomic and proteomic profiling of glial versus neuronal Dube3a overexpression reveals common molecular changes in gliopathic epilepsies. Hope KA, et al. Neurobiol Dis, 2020 Jul. PMID 32344153, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in jump response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in optomotor response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetratricopeptide repeat domain 19
    Names
    CG15173-PA
    Ttc19-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19043535..19045148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136090.3 → NP_609934.3  tetratricopeptide repeat domain 19 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609934.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYD0, Q9VJ13
      Related
      FBpp0080720
      Conserved Domains (3) summary
      sd00006
      Location:269 → 299
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:272 → 339
      TPR_11; TPR repeat
      pfam13424
      Location:235 → 302
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYD0.1 Q8SYD0

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