Hmgcl 3-Hydroxymethyl-3-methylglutaryl-CoA lyase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hmgclprovided by FlyBase
Official Full Name: 3-Hydroxymethyl-3-methylglutaryl-CoA lyaseprovided by FlyBase
Primary source: FLYBASE:FBgn0031877
Locus tag: Dmel_CG10399
See related: AllianceGenome:FB:FBgn0031877
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 145934_at; CG10399; Dmel\CG10399; HMGCL
Summary: Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in L-leucine catabolic process and ketone body biosynthetic process. Predicted to be located in cytosol; endoplasmic reticulum; and peroxisome. Is expressed in adult head. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency and amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6960377..6961653)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6960377..6961653)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Function	Evidence Code	Pubs
enables hydroxymethylglutaryl-CoA lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydroxymethylglutaryl-CoA lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxo-acid-lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ketone body biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ketone body biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_001285696.1

NP_609089.1

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The following sections contain reference sequences that belong to a specific genome build. Explain