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    haf hattifattener [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hafprovided by FlyBase
    Official Full Name
    hattifattenerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261509
    Locus tag
    Dmel_CG14351
    See related
    AllianceGenome:FB:FBgn0261509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14351; CT33985; Dmel\CG14351; tartan/capricious-like
    Summary
    Involved in motor neuron axon guidance. Is expressed in larval central nervous system and larval somatic muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See haf in Genome Data Viewer
    Location:
    22A3-22A3; 2-3 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1555129..1609389)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1555129..1608404)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Odorant receptor 22a Neighboring gene Odorant receptor 22b Neighboring gene no individualized sperm Neighboring gene RAB3 GTPase activating protein subunit 1 Neighboring gene long non-coding RNA:CR44603 Neighboring gene uncharacterized protein Neighboring gene Rieske iron-sulfur protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Satellite Repeats Identify X Chromatin for Dosage Compensation in Drosophila melanogaster Males. Joshi SS, et al. Curr Biol, 2017 May 22. PMID 28457869, Free PMC Article
    2. Screening of suppressors of bax-induced cell death identifies glycerophosphate oxidase-1 as a mediator of debcl-induced apoptosis in Drosophila. Colin J, et al. Genes Cancer, 2015 May. PMID 26124923, Free PMC Article
    3. Chromatin That Guides Dosage Compensation Is Modulated by the siRNA Pathway in Drosophila melanogaster. Deshpande N, et al. Genetics, 2018 Aug. PMID 29921620, Free PMC Article
    4. The Molecular and Genetic Characterization of Second Chromosome Balancers in Drosophila melanogaster. Miller DE, et al. G3 (Bethesda), 2018 Mar 28. PMID 29420191, Free PMC Article
    5. A screen of cell-surface molecules identifies leucine-rich repeat proteins as key mediators of synaptic target selection. Kurusu M, et al. Neuron, 2008 Sep 25. PMID 18817735, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 1570745-1573554 mobile_element_type = transposon:F{}287

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hattifattener
    Names
    CG14351-PB
    CG14351-PC
    CG14351-PD
    CG14351-PE
    CG14351-PF
    CG14351-PG
    CG14351-PH
    CG14351-PI
    haf-PB
    haf-PC
    haf-PD
    haf-PE
    haf-PF
    haf-PG
    haf-PH
    haf-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1555129..1609389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272945.2 → NP_001259874.1  hattifattener, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259874.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FB93, M9PC50
      Conserved Domains (6) summary
      smart00370
      Location:300 → 323
      LRR; Leucine-rich repeats, outliers
      cd00116
      Location:39 → 238
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:106 → 129
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:224 → 267
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:131 → 189
      LRR_8; Leucine rich repeat
      cl15307
      Location:362 → 414
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    2. NM_001272946.1 → NP_001259875.1  hattifattener, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259875.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FB93, Q9VQ25
      Conserved Domains (6) summary
      smart00370
      Location:300 → 323
      LRR; Leucine-rich repeats, outliers
      cd00116
      Location:39 → 238
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:106 → 129
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:224 → 267
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:131 → 189
      LRR_8; Leucine rich repeat
      cl15307
      Location:362 → 414
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    3. NM_134763.2 → NP_608607.2  hattifattener, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608607.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FB93, Q9VQ25
      Conserved Domains (6) summary
      smart00370
      Location:300 → 323
      LRR; Leucine-rich repeats, outliers
      cd00116
      Location:39 → 238
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:106 → 129
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:224 → 267
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:131 → 189
      LRR_8; Leucine rich repeat
      cl15307
      Location:362 → 414
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    4. NM_001298635.1 → NP_001285564.1  hattifattener, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285564.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FB93, X2J6N9
      Conserved Domains (6) summary
      smart00370
      Location:300 → 323
      LRR; Leucine-rich repeats, outliers
      cd00116
      Location:39 → 238
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:106 → 129
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:224 → 267
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:131 → 189
      LRR_8; Leucine rich repeat
      cl15307
      Location:362 → 414
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    5. NM_001369974.1 → NP_001356952.1  hattifattener, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K0X3, F2FB93
      Conserved Domains (4) summary
      TIGR00864
      Location:332 → 413
      PCC; polycystin cation channel protein
      COG4886
      Location:52 → 252
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:106 → 129
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:131 → 189
      LRR_8; Leucine rich repeat

    6. NM_001369975.1 → NP_001356953.1  hattifattener, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K216, F2FB93
      Conserved Domains (4) summary
      TIGR00864
      Location:332 → 413
      PCC; polycystin cation channel protein
      COG4886
      Location:52 → 252
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:106 → 129
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:131 → 189
      LRR_8; Leucine rich repeat

    7. NM_001369976.1 → NP_001356954.1  hattifattener, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K327
      Conserved Domains (5) summary
      TIGR00864
      Location:332 → 413
      PCC; polycystin cation channel protein
      COG4886
      Location:52 → 252
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      PRK10927
      Location:1061 → 1097
      PRK10927; essential cell division protein FtsN; Provisional
      sd00033
      Location:106 → 129
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:131 → 189
      LRR_8; Leucine rich repeat

    8. NM_001272944.1 → NP_001259873.1  hattifattener, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FB93, M9PC50
      Conserved Domains (6) summary
      smart00370
      Location:300 → 323
      LRR; Leucine-rich repeats, outliers
      cd00116
      Location:39 → 238
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:106 → 129
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:224 → 267
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:131 → 189
      LRR_8; Leucine rich repeat
      cl15307
      Location:362 → 414
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K0X3 A0A4D6K0X3
    A0A4D6K216 A0A4D6K216
    A0A4D6K327 A0A4D6K327
    M9PC50 M9PC50
    Q9VQ25 Q9VQ25
    X2J6N9 X2J6N9

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