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    ppk23 pickpocket 23 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32731, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppk23provided by FlyBase
    Official Full Name
    pickpocket 23provided by FlyBase
    Primary source
    FLYBASE:FBgn0030844
    Locus tag
    Dmel_CG8527
    See related
    AllianceGenome:FB:FBgn0030844
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8527; Dmel\CG8527; ppk-23; PPK-23; Ppk23; PPK23
    Summary
    Predicted to enable ligand-gated sodium channel activity. Involved in detection of pheromone and male courtship behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult prothoracic segment; appendage; ganglia; gustatory receptor neurons; and labellum. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppk23 in Genome Data Viewer
    Location:
    16B4-16B4; 1-57 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17566552..17569228, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17460585..17463261, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44692 Neighboring gene antisense RNA:CR44124 Neighboring gene Ankle2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Measuring Physiological Responses of Drosophila Sensory Neurons to Lipid Pheromones Using Live Calcium Imaging. Shankar S, et al. J Vis Exp, 2016 Apr 29. PMID 27168110, Free PMC Article
    2. Evolution of a central neural circuit underlies Drosophila mate preferences. Seeholzer LF, et al. Nature, 2018 Jul. PMID 29995860, Free PMC Article
    3. The Drosophila female aphrodisiac pheromone activates ppk23(+) sensory neurons to elicit male courtship behavior. Toda H, et al. Cell Rep, 2012 Jun 28. PMID 22813735
    4. Larval microbiota primes the Drosophila adult gustatory response. Montanari M, et al. Nat Commun, 2024 Feb 13. PMID 38351056, Free PMC Article
    5. Regulation of sleep homeostasis by sexual arousal. Beckwith EJ, et al. Elife, 2017 Sep 12. PMID 28893376, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data identify the ppk23(+) sensory neurons as the primary targets for female sex pheromones in Drosophila.
      Title: The Drosophila female aphrodisiac pheromone activates ppk23(+) sensory neurons to elicit male courtship behavior.
    2. these data indicate that ppk23 and the cells expressing it play an important role in the peripheral sensory system that determines sexual behavior in Drosophila.
      Title: ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated sodium channel activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in detection of pheromone IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_positive_effect male courtship behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pickpocket 23
    Names
    CG8527-PA
    CG8527-PB
    CG8527-PC
    CG8527-PD
    ppk23-PA
    ppk23-PB
    ppk23-PC
    ppk23-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17566552..17569228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272717.1 → NP_001259646.1  pickpocket 23, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259646.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F8QU26, M9PHF4
      Conserved Domains (1) summary
      pfam00858
      Location:34 → 451
      ASC; Amiloride-sensitive sodium channel

    2. NM_001103541.3 → NP_001097011.1  pickpocket 23, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097011.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JV41, F8QU26
      Conserved Domains (1) summary
      pfam00858
      Location:34 → 476
      ASC; Amiloride-sensitive sodium channel

    3. NM_132992.3 → NP_573220.2  pickpocket 23, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573220.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86LG2, Q9VX46
      Conserved Domains (1) summary
      pfam00858
      Location:34 → 451
      ASC; Amiloride-sensitive sodium channel

    4. NM_001014749.2 → NP_001014749.1  pickpocket 23, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014749.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86LG2, Q86LG3
      Conserved Domains (1) summary
      pfam00858
      Location:34 → 476
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JV41 A8JV41
    M9PHF4 M9PHF4
    Q86LG2 Q86LG2
    Q86LG3 Q86LG3
    Q9VX46 Q9VX46

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