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    THG tRNA-histidine guanylyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34876, updated on 4-Jan-2025

    Summary

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    Official Symbol
    THGprovided by FlyBase
    Official Full Name
    tRNA-histidine guanylyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283659
    Locus tag
    Dmel_CG4103
    See related
    AllianceGenome:FB:FBgn0283659
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00929.4; br4; C1; CG4103; Dmel\CG4103; l(2)35Bc; l(2)br; l(2)br11; l(2)br13; l(2)br4; l(2)k08808; tRNA-guanylyltransferase
    Summary
    Predicted to enable tRNA guanylyltransferase activity. Predicted to be involved in tRNA modification. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 28. Orthologous to human THG1L (tRNA-histidine guanylyltransferase 1 like). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See THG in Genome Data Viewer
    Location:
    35B8-35B8; 2-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15008489..15009724, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15008489..15009724, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene moladietz Neighboring gene Dynactin 5, p25 subunit Neighboring gene Ankrd49 Neighboring gene Negative Cofactor 2beta Neighboring gene long non-coding RNA:CR43856 Neighboring gene RNA guanine-7 methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enzymatic addition of guanylate to histidine transfer RNA. Williams JB, et al. Methods Enzymol, 1990. PMID 2166216
    2. Structural studies of a bacterial tRNA(HIS) guanylyltransferase (Thg1)-like protein, with nucleotide in the activation and nucleotidyl transfer sites. Hyde SJ, et al. PLoS One, 2013. PMID 23844012, Free PMC Article
    3. Molecular analysis of the Adh region of the genome of Drosophila melanogaster. Chia W, et al. J Mol Biol, 1985 Dec 20. PMID 3005593
    4. Genetic and phenotypic analysis of the genes of the elbow-no-ocelli region of chromosome 2L of Drosophila melanogaster. Davis T, et al. Hereditas, 1997. PMID 9175495
    5. The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. III. Hypomorphic and hypermorphic mutations affecting the expression of hairless. Ashburner M. Genetics, 1982 Jul-Aug. PMID 6816670, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA guanylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA guanylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA guanylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-histidine guanylyltransferase
    Names
    CG4103-PA
    CG4103-PB
    THG-PA
    THG-PB
    lethal (2) 35Bc
    lethal 11 in the black-reduced region
    lethal 13 in the black-reduced region
    lethal 4 in the black-reduced region
    lethal group C1
    tRNA guanylyltransferase
    NP_001188815.1
    NP_609737.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15008489..15009724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201886.1 → NP_001188815.1  tRNA-histidine guanylyltransferase, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9MSI6, Q9V3N8
      Conserved Domains (3) summary
      COG4021
      Location:2 → 239
      Thg1; tRNA(His) 5'-end guanylyltransferase [Translation, ribosomal structure and biogenesis]
      pfam04446
      Location:9 → 134
      Thg1; tRNAHis guanylyltransferase
      pfam14413
      Location:137 → 234
      Thg1C; Thg1 C terminal domain

    2. NM_135893.2 → NP_609737.1  tRNA-histidine guanylyltransferase, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9MSI6, Q9V3N8
      Related
      FBpp0080286
      Conserved Domains (3) summary
      COG4021
      Location:2 → 239
      Thg1; tRNA(His) 5'-end guanylyltransferase [Translation, ribosomal structure and biogenesis]
      pfam04446
      Location:9 → 134
      Thg1; tRNAHis guanylyltransferase
      pfam14413
      Location:137 → 234
      Thg1C; Thg1 C terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3N8.1 Q9V3N8

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