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    mRpL18 mitochondrial ribosomal protein L18 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36406, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mRpL18provided by FlyBase
    Official Full Name
    mitochondrial ribosomal protein L18provided by FlyBase
    Primary source
    FLYBASE:FBgn0026741
    Locus tag
    Dmel_CG12373
    See related
    AllianceGenome:FB:FBgn0026741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-49Ca; CG12373; Dmel\CG12373; HL; MRP-L18
    Summary
    Predicted to enable 5S rRNA binding activity. Predicted to be involved in rRNA import into mitochondrion. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human MRPL18 (mitochondrial ribosomal protein L18). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mRpL18 in Genome Data Viewer
    Location:
    49C2-49C2; 2-67 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12756434..12757173)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8643939..8644678)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mos oncogene Neighboring gene Diacyl glycerol kinase epsilon Neighboring gene Tafazzin Neighboring gene Nascent polypeptide associated complex protein alpha subunit Neighboring gene oxen Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila MOS ortholog is not essential for meiosis. Ivanovska I, et al. Curr Biol, 2004 Jan 6. PMID 14711418
    2. The oxen gene of Drosophila encodes a homolog of subunit 9 of yeast ubiquinol-cytochrome c oxidoreductase complex: evidence for modulation of gene expression in response to mitochondrial activity. Frolov MV, et al. Genetics, 2000 Dec. PMID 11102369, Free PMC Article
    3. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. Koc EC, et al. J Biol Chem, 2001 Nov 23. PMID 11551941
    4. Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila. Vesala L, et al. BMC Biol, 2024 Mar 13. PMID 38475850, Free PMC Article
    5. The ribosomal protein genes and Minute loci of Drosophila melanogaster. Marygold SJ, et al. Genome Biol, 2007. PMID 17927810, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5S rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5S rRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in rRNA import into mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial ribosomal protein L18
    Names
    CG12373-PA
    mRpL18-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12756434..12757173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136974.3 → NP_610818.1  mitochondrial ribosomal protein L18 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610818.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVK1, Q9XY36
      Related
      FBpp0086965
      Conserved Domains (1) summary
      cd00432
      Location:50 → 150
      Ribosomal_L18_L5e; Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JVK1 Q7JVK1
    Q9XY36 Q9XY36

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