Dop1R2 Dopamine 1-like receptor 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dop1R2provided by FlyBase
Official Full Name: Dopamine 1-like receptor 2provided by FlyBase
Primary source: FLYBASE:FBgn0266137
Locus tag: Dmel_CG18741
See related: AllianceGenome:FB:FBgn0266137
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18741; CG7569; D1R2; D2R; damb; Damb; DAMB; Dar2; DDR2; DmDOP2; Dmel\CG18741; Dop1r2; DopD1; DopR; dopr2; DopR2; DOPR2; DopR99B; DOPR99B; DopRII; DR2; K13sc
Summary: Enables dopamine neurotransmitter receptor activity, coupled via Gs and tyramine receptor activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; regulation of presynaptic cytosolic calcium ion concentration; and response to odorant. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult mushroom body alpha-lobe; adult mushroom body beta-lobe; lobe system of mushroom body; mushroom body; and mushroom body spur. Human ortholog(s) of this gene implicated in Alzheimer's disease; heroin dependence; and hypertension. Orthologous to several human genes including ADRA1D (adrenoceptor alpha 1D). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 99B5-99B6; 3-99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29630304..29659984, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25456026..25485706, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Damb receptor uniquely activates Gq to mobilize Ca(2+) signaling with greater efficiency and dopamine sensitivity
Title: Dopamine Receptor DAMB Signals via Gq to Mediate Forgetting in Drosophila.
Findings suggest a role for dopamine D1-like receptor Dop1R2 in the repression of genes that coordinate metamorphosis.
Title: A critical role for the Drosophila dopamine D1-like receptor Dop1R2 at the onset of metamorphosis.
Results suggest that the activation state of DAMB protein contributes to oxidative stress susceptibility in Drosophila and lead to a proposed model for paraquat neurotoxicity.
Title: A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila.
DD2R gene is expressed in the fat body, and its expression is higher in young females than in sexually mature females. The DD2R gene expression was not detected in ovarian follicular cells.
Title: [Effect of sexual maturation on DD2R gene expression in fat body of Drosophila melanogaster females].

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c29655470-29653114 mobile_element_type = transposon:jockey{}1452

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables dopamine neurotransmitter receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gs	IDA Inferred from Direct Assay more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gs	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables tyramine receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to dopamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to odorant	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISM Inferred from Sequence Model more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in synaptic vesicle membrane	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: dopamine 1-like receptor 2

Names: CG18741-PA; CG18741-PB; CG18741-PC; DAMB DA receptor; D[[2]]-like receptor; Dop1R2-PA; Dop1R2-PB; Dop1R2-PC; K13sc; damb; dopamine receptor 2; dopamine receptor in mushroom bodies; dopamine receptor in mushroom body; dopamine-2 receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

29630304..29659984 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170420.2 → NP_733299.1 dopamine 1-like receptor 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733299.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24563

Related

FBpp0084833

Conserved Domains (2) summary

pfam00001
Location:125 → 474

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:123 → 295

7tm_4; Olfactory receptor
NM_001276143.1 → NP_001263072.1 dopamine 1-like receptor 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263072.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KI18

Conserved Domains (2) summary

pfam00001
Location:125 → 474

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:123 → 295

7tm_4; Olfactory receptor
NM_079824.4 → NP_524548.1 dopamine 1-like receptor 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524548.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24563, Q24569, Q9VAJ8

Related

FBpp0084834

Conserved Domains (2) summary

pfam00001
Location:125 → 474

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:123 → 295

7tm_4; Olfactory receptor