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    MAPk-Ak2 MAP kinase activated protein-kinase-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44573, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MAPk-Ak2provided by FlyBase
    Official Full Name
    MAP kinase activated protein-kinase-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0013987
    Locus tag
    Dmel_CG3086
    See related
    AllianceGenome:FB:FBgn0013987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2
    Summary
    Predicted to enable calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of cell size; regulation of JNK cascade; and response to salt stress. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head; organism; and ovary. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to several human genes including MAPKAPK3 (MAPK activated protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MAPk-Ak2 in Genome Data Viewer
    Location:
    5B8-5B8; 1-13 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5759908..5764203, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5653941..5658236, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45528 Neighboring gene lin-52 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila melanogaster homolog of the mammalian MAPK-activated protein kinase-2 (MAPKAPK-2) lacks a proline-rich N-terminus. Larochelle S, et al. Gene, 1995 Oct 3. PMID 7590268
    2. MK3 controls Polycomb target gene expression via negative feedback on ERK. Prickaerts P, et al. Epigenetics Chromatin, 2012 Aug 7. PMID 22870894, Free PMC Article
    3. The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU. Tian L, et al. J Biol Chem, 2014 Nov 14. PMID 25204651, Free PMC Article
    4. MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress. Seisenbacher G, et al. PLoS Genet, 2011 Aug. PMID 21829386, Free PMC Article
    5. Changes in Drosophila melanogaster midgut proteins in response to dietary Bowman-Birk inhibitor. Li HM, et al. Insect Mol Biol, 2007 Oct. PMID 17725801

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IscU is a new substrate of MK2 both in Drosophila cells and in human cells
      Title: The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitogen-activated protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mitochondrial electron transport, NADH to ubiquinone IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase activated protein-kinase-2
    Names
    CG3086-PB
    CG3086-PD
    CG3086-PE
    CG3086-PF
    MAP kinase activated protein kinase-2
    MAP kinase-activated protein kinase 2
    MAPk-Ak2-PB
    MAPk-Ak2-PD
    MAPk-Ak2-PE
    MAPk-Ak2-PF
    NP_001188547.1
    NP_001245536.1
    NP_524769.1
    NP_788861.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5759908..5764203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080030.5 → NP_524769.1  MAP kinase activated protein-kinase-2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524769.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49071, Q9W480
      UniProtKB/TrEMBL
      A4V402
      Related
      FBpp0070802
      Conserved Domains (2) summary
      smart00220
      Location:25 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14089
      Location:18 → 280
      STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases

    2. NM_176688.3 → NP_788861.1  MAP kinase activated protein-kinase-2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788861.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49071, Q9W480
      UniProtKB/TrEMBL
      A4V402
      Related
      FBpp0070804
      Conserved Domains (2) summary
      smart00220
      Location:25 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14089
      Location:18 → 280
      STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases

    3. NM_001201618.1 → NP_001188547.1  MAP kinase activated protein-kinase-2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49071, Q9W480
      UniProtKB/TrEMBL
      A4V402
      Conserved Domains (2) summary
      smart00220
      Location:25 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14089
      Location:18 → 280
      STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases

    4. NM_001258607.2 → NP_001245536.1  MAP kinase activated protein-kinase-2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245536.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49071, Q9W480
      UniProtKB/TrEMBL
      A4V402
      Conserved Domains (2) summary
      smart00220
      Location:25 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14089
      Location:18 → 280
      STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V402 A4V402
    P49071.1 P49071
    Q8T9D6 Q8T9D6

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