Uro Urate oxidase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Uroprovided by FlyBase
Official Full Name: Urate oxidaseprovided by FlyBase
Primary source: FLYBASE:FBgn0003961
Locus tag: Dmel_CG7171
See related: AllianceGenome:FB:FBgn0003961
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0140519.210; CG7171; Dm UO; Dmel\CG7171; OU; Uo; UO; UOX; uro; URO
Summary: Predicted to enable urate oxidase activity. Predicted to be involved in purine nucleobase catabolic process and urate catabolic process. Predicted to be active in peroxisome. Is expressed in Malpighian tubule; adult Malpighian tubule principal cell of main segment; adult head; and main segment of Malpighian tubule. Used to study hyperuricemia. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (7780085..7781415)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (7780085..7781415)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

coproporphyrinogen III oxidase sequence matches many structural features from urate oxidase
Title: Towards a new T-fold protein?: the coproporphyrinogen III oxidase sequence matches many structural features from urate oxidase.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables urate oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables urate oxidase activity	IEA Inferred from Electronic Annotation more info
enables urate oxidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in allantoin biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in purine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
involved_in urate catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	ISM Inferred from Sequence Model more info	PubMed
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_476779.1

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The following sections contain reference sequences that belong to a specific genome build. Explain