Est-6 Esterase 6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Est-6provided by FlyBase
Official Full Name: Esterase 6provided by FlyBase
Primary source: FLYBASE:FBgn0000592
Locus tag: Dmel_CG6917
See related: AllianceGenome:FB:FBgn0000592
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6917; Dmel\CG6917; Est; Est 6; Est-5; EST-5; Est-5B; est-6; EST-6; Est-D; est6; Est6; EST6
Summary: Enables carboxylesterase activity and short-chain carboxylesterase activity. Involved in courtship behavior; pheromone biosynthetic process; and response to odorant. Located in extracellular region. Is expressed in adult head; adult heart; amnioserosa; embryonic/larval fat body; and yolk nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 69A1-69A1; 3-38 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12188818..12190705)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12181918..12183805)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data support a model in which esterase 6 acts as a direct odorant degrading enzyme for many bioactive food esters, but not cis-vaccenyl acetate.
Title: Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila.
These results expand the role of Est-6 in Drosophila biology, from reproduction to olfaction, and highlight the role of odorant-degrading enzymes in insect olfaction.
Title: A carboxylesterase, Esterase-6, modulates sensory physiological and behavioral response dynamics to pheromone in Drosophila.
Intergenic epistatic selection between Est-6 and psiEst-6 may play an important role in the evolution of the beta-esterase gene cluster preserving the putative pseudogene from degenerative destruction
Title: Molecular population genetics of the beta-esterase gene cluster of Drosophila melanogaster.
Molecular evolution of this gene was studied.
Title: Positive and negative selection in the beta-esterase gene cluster of the Drosophila melanogaster subgroup.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables carboxylesterase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables peptidase activity	IKR Inferred from Key Residues more info
enables serine hydrolase activity	HDA more info	PubMed
enables short-chain carboxylesterase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating	TAS Traceable Author Statement more info	PubMed
involved_in ovulation	TAS Traceable Author Statement more info	PubMed
involved_in pheromone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pheromone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of egg-laying behavior	TAS Traceable Author Statement more info	PubMed
involved_in regulation of female receptivity, post-mating	TAS Traceable Author Statement more info	PubMed
involved_in response to odorant	IDA Inferred from Direct Assay more info	PubMed
involved_in sexual reproduction	HEP more info	PubMed
NOT involved_in sperm competition	TAS Traceable Author Statement more info	PubMed
involved_in sperm storage	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: esterase 6

Names: CG6917-PA; CG6917-PB; Est-6-PA; Est-6-PB; Esterase-6; Esterase6; Stress-inducible humoral factor turandot A; carboxyl ester hydrolase

NP_001261749.1

EC 3.1.1.1

NP_788500.1

EC 3.1.1.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

12188818..12190705

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274820.1 → NP_001261749.1 esterase 6, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261749.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08171, P91646, P91647, P91648, P91649, P91650, P92173, P92195, P92200, Q867G7, Q867V2, Q867Y9, Q868B8, Q86CX4, Q86CX5, Q86CX6, Q86CX7, Q86CX8, Q86CX9, Q86CY0, Q86CY1, Q86CY2, Q86CY3, Q86CY4, Q86CY5, Q86CY6, Q86CY7, Q8SWT4, Q9U797, Q9U798, Q9U799, Q9U7A0, Q9V3U8, Q9XTN6

UniProtKB/TrEMBL

A0A0U3SHB6, C9QP21

Conserved Domains (2) summary

COG0657
Location:110 → 243

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

cd00312
Location:29 → 537

Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
NM_176322.3 → NP_788500.1 esterase 6, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788500.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08171, P91646, P91647, P91648, P91649, P91650, P92173, P92195, P92200, Q867G7, Q867V2, Q867Y9, Q868B8, Q86CX4, Q86CX5, Q86CX6, Q86CX7, Q86CX8, Q86CX9, Q86CY0, Q86CY1, Q86CY2, Q86CY3, Q86CY4, Q86CY5, Q86CY6, Q86CY7, Q8SWT4, Q9U797, Q9U798, Q9U799, Q9U7A0, Q9V3U8, Q9XTN6

UniProtKB/TrEMBL

A0A0U3SHB6, C9QP21

Related

FBpp0075735

Conserved Domains (2) summary

COG0657
Location:110 → 243

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

cd00312
Location:29 → 537

Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...