mRpL12 mitochondrial ribosomal protein L12 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mRpL12provided by FlyBase
Official Full Name: mitochondrial ribosomal protein L12provided by FlyBase
Primary source: FLYBASE:FBgn0011787
Locus tag: Dmel_CG5012
See related: AllianceGenome:FB:FBgn0011787
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE53508; CG5012; Dmel\CG5012; l(3)10534; l(3)j4B2; l(3)rL424; L7; L7/12A; L7/L12; Mrp17; MRPL12; mRpL7-L12
Summary: Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Involved in positive regulation of cell growth and regulation of mitochondrion organization. Located in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and larval somatic muscle cell. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 45. Orthologous to human MRPL12 (mitochondrial ribosomal protein L12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8956791..8957584)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8949891..8950684)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

mRpL12 is required for CycD/Cdk4-induced cell growth
Title: The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial translation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mitochondrial large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial large ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of mitochondrial large ribosomal subunit	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in ribosome	IEA Inferred from Electronic Annotation more info

Names: CG5012-PA; mRpL12-PA; mitochondrial ribosomal protein L5/L17; mitochondrial ribosomal protein L7/L12

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