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    Pym Partner of Y14 and Mago [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37780, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pymprovided by FlyBase
    Official Full Name
    Partner of Y14 and Magoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034918
    Locus tag
    Dmel_CG30176
    See related
    AllianceGenome:FB:FBgn0034918
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:HL05757; CG10330; CG30176; Dmel\CG30176; pym; PYM; UD3; wibg; Wibg
    Summary
    Enables RNA binding activity and exon-exon junction complex binding activity. Involved in exon-exon junction complex disassembly. Located in cytoplasm. Part of exon-exon junction complex. Is expressed in follicle cell; germarium; nurse cell; oocyte; and organism. Orthologous to human PYM1 (PYM homolog 1, exon junction complex associated factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pym in Genome Data Viewer
    Location:
    60A4-60A4; 2-105 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23855954..23856936, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19743477..19744459, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene yantar Neighboring gene antisense RNA:CR45928 Neighboring gene glass bottom boat Neighboring gene benign gonial cell neoplasm Neighboring gene TAR DNA-binding protein-43 homolog Neighboring gene Ceramide phosphoethanolamine synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. Bono F, et al. EMBO Rep, 2004 Mar. PMID 14968132, Free PMC Article
    2. The EJC disassembly factor PYM is an intrinsically disordered protein and forms a fuzzy complex with RNA. Verma D, et al. Front Mol Biosci, 2023. PMID 37065448, Free PMC Article
    3. Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13. Bono F, et al. Mol Cell, 2010 Jan 29. PMID 20122403
    4. The Drosophila cystoblast differentiation factor, benign gonial cell neoplasm, is related to DExH-box proteins and interacts genetically with bag-of-marbles. Ohlstein B, et al. Genetics, 2000 Aug. PMID 10924476, Free PMC Article
    5. RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. Forler D, et al. Mol Cell Biol, 2004 Feb. PMID 14729961, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables eukaryotic initiation factor 4E binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables eukaryotic initiation factor 4G binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables exon-exon junction complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables ribosomal small subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables ribosomal small subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in cap-dependent translational initiation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in exon-exon junction complex disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exon-exon junction complex disassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exon-exon junction complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exon-exon junction complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    partner of Y14 and mago
    Names
    CG30176-PA
    Pym-PA
    undefined 3
    within bgcn

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23855954..23856936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166627.3 → NP_726372.1  partner of Y14 and mago [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726372.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P82804
      Related
      FBpp0072142
      Conserved Domains (1) summary
      pfam09282
      Location:11 → 35
      Mago-bind; Mago binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P82804.1 P82804

    Gene LinkOut

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