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    PH4alphaEFB prolyl-4-hydroxylase-alpha EFB [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43620, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PH4alphaEFBprovided by FlyBase
    Official Full Name
    prolyl-4-hydroxylase-alpha EFBprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039776
    Locus tag
    Dmel_CG31022
    See related
    AllianceGenome:FB:FBgn0039776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD05564; CG12088; CG1473; CG31022; Dmel\CG31022; PH4-aEFB; PH4alpha-EFB
    Summary
    Predicted to enable procollagen-proline 4-dioxygenase activity. Located in endomembrane system. Is expressed in several structures, including adult brain cell body rind; adult head; dorsal epidermis primordium; embryonic dorsal epidermis; and follicle cell. Human ortholog(s) of this gene implicated in myopia. Orthologous to several human genes including P4HA1 (prolyl 4-hydroxylase subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PH4alphaEFB in Genome Data Viewer
    Location:
    99F6-99F6; 3-100 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30466050..30485799)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26291772..26311521)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ceramidase Neighboring gene sanpodo Neighboring gene Jonah 99Fii Neighboring gene Jonah 99Fi

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic regulation of basement membrane protein levels promotes egg chamber elongation in Drosophila. Isabella AJ, et al. Dev Biol, 2015 Oct 15. PMID 26348027, Free PMC Article
    2. Biosynthesis and assembly of the Collagen IV-like protein Pericardin in Drosophila melanogaster. Wilmes AC, et al. Biol Open, 2018 Apr 23. PMID 29685999, Free PMC Article
    3. Variations in basement membrane mechanics are linked to epithelial morphogenesis. Chlasta J, et al. Development, 2017 Dec 1. PMID 29038305
    4. Ceramidase regulates synaptic vesicle exocytosis and trafficking. Rohrbough J, et al. J Neurosci, 2004 Sep 8. PMID 15356190, Free PMC Article
    5. Companion Blood Cells Control Ovarian Stem Cell Niche Microenvironment and Homeostasis. Van De Bor V, et al. Cell Rep, 2015 Oct 20. PMID 26456819

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prolyl-4-hydroxylase-alpha EFB
    Names
    CG31022-PA
    PH4alphaEFB-PA
    propyl-4-hydroxylase-alpha EFB
    NP_733371.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30466050..30485799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170492.2 → NP_733371.1  prolyl-4-hydroxylase-alpha EFB [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960D8, Q9VA69
      Related
      FBpp0085012
      Conserved Domains (2) summary
      smart00702
      Location:356 → 529
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:28 → 159
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VA69 Q9VA69

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