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    Cdlc2 Cytoplasmic dynein light chain 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33319, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdlc2provided by FlyBase
    Official Full Name
    Cytoplasmic dynein light chain 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0026141
    Locus tag
    Dmel_CG5450
    See related
    AllianceGenome:FB:FBgn0026141
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.117; Cdcl2; CG5450; dDYNLL2; dlc; Dlc; Dmel\CG5450
    Summary
    Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based process. Predicted to be part of cytoplasmic dynein complex. Is expressed in adult head; spermatozoon; and testis. Orthologous to several human genes including DYNLL2 (dynein light chain LC8-type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cdlc2 in Genome Data Viewer
    Location:
    22A1-22A1; 2-3 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1344400..1345135)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1344400..1345135)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45005 Neighboring gene long non-coding RNA:CR45006

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The intermediate chain of cytoplasmic dynein is partially disordered and gains structure upon binding to light-chain LC8. Nyarko A, et al. Biochemistry, 2004 Dec 14. PMID 15581372
    2. Modelling active transport in Drosophila unipolar motor neurons. Kuznetsov AV. Comput Methods Biomech Biomed Engin, 2011 Dec. PMID 21337219
    3. Multivalency in the assembly of intrinsically disordered Dynein intermediate chain. Hall J, et al. J Biol Chem, 2009 Nov 27. PMID 19759397, Free PMC Article
    4. Bicaudal-D regulates fragile X mental retardation protein levels, motility, and function during neuronal morphogenesis. Bianco A, et al. Curr Biol, 2010 Aug 24. PMID 20691595, Free PMC Article
    5. PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development. Liu K, et al. Dev Cell, 2019 Aug 19. PMID 31327739, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show assembled dynein IC as an elongated, flexible polybivalent duplex, and suggest that polybivalency is an important general mechanism for constructing stable yet reversible and functionally versatile complexes.
      Title: Multivalency in the assembly of intrinsically disordered Dynein intermediate chain.
    2. We propose that Msn functions together with Bic-D to regulate the apical localization of dynein in generating directed nuclear migration within differentiating R-cell precursor cells.
      Title: The Ste20-like kinase misshapen functions together with Bicaudal-D and dynein in driving nuclear migration in the developing drosophila eye.
    3. The induced folding of cytoplasmic dynein intermediate chain IC(1-289) upon LC8 light chain binding suggests that LC8 could act through the intermediate chain to facilitate dynein assembly or regulate cargo-binding interactions.
      Title: The intermediate chain of cytoplasmic dynein is partially disordered and gains structure upon binding to light-chain LC8.
    4. dynein-dynactin, abnormal spindle protein (Asp), and KLP10A have roles in Drosophila spindle pole organization
      Title: Spindle pole organization in Drosophila S2 cells by dynein, abnormal spindle protein (Asp), and KLP10A.
    5. Dynein light chain 1 regulates dynamin-mediated F-actin assembly during sperm individualization in Drosophila
      Title: Dynein light chain 1 regulates dynamin-mediated F-actin assembly during sperm individualization in Drosophila.
    6. Dynein-mediated transport of specific RNAs along specialized networks of microtubules increases the efficiency of their delivery, over the flow of general cytoplasmic components, into the oocyte
      Title: A Dynein-dependent shortcut rapidly delivers axis determination transcripts into the Drosophila oocyte.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic dynein light chain 2
    Names
    8kd dynein light chain
    CG5450-PA
    CG5450-PB
    CG5450-PC
    Cdlc2-PA
    Cdlc2-PB
    Cdlc2-PC
    cyto dynein light chain 2
    cytoplasmic dynein
    dynein
    dynein light chain type 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1344400..1345135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258907.2 → NP_001245836.1  cytoplasmic dynein light chain 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245836.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZY5, C6SUZ4, O96860, Q541G4
      UniProtKB/TrEMBL
      M9NDC7
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

    2. NM_058060.4 → NP_477408.1  cytoplasmic dynein light chain 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477408.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZY5, C6SUZ4, O96860, Q541G4
      UniProtKB/TrEMBL
      M9NDC7
      Related
      FBpp0077590
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

    3. NM_164412.2 → NP_722698.1  cytoplasmic dynein light chain 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722698.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZY5, C6SUZ4, O96860, Q541G4
      UniProtKB/TrEMBL
      M9NDC7
      Related
      FBpp0077591
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDC7 M9NDC7
    O96860.1 O96860

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