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    Rhobtb3 Rho-related BTB domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 73296, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rhobtb3provided by MGI
    Official Full Name
    Rho-related BTB domain containing 3provided by MGI
    Primary source
    MGI:MGI:1920546
    See related
    Ensembl:ENSMUSG00000021589 AllianceGenome:MGI:1920546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0878; 1700040C17Rik; 2610033K01Rik; 4930503C18Rik
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and enzyme binding activity. Acts upstream of or within male gonad development. Located in cytoplasm. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; respiratory system; and skeletal musculature. Orthologous to human RHOBTB3 (Rho related BTB domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.7), limb E14.5 (RPKM 9.8) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rhobtb3 in Genome Data Viewer
    Location:
    13 C1; 13 40.95 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (76017656..76092054, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (75869537..75943824, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 41005 Neighboring gene STARR-seq mESC enhancer starr_35051 Neighboring gene glutaredoxin Neighboring gene predicted gene, 24163 Neighboring gene WD repeat domain 77 pseudogene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene spermatogenesis associated 9 Neighboring gene predicted gene, 23319

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho-related BTB domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418860.1NP_001405789.1  rho-related BTB domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122242, AC158356
    2. NM_028493.3NP_082769.1  rho-related BTB domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_082769.1

      Status: VALIDATED

      Source sequence(s)
      AC122242, AC158356
      Consensus CDS
      CCDS26652.1
      UniProtKB/Swiss-Prot
      Q05DP2, Q3UTS4, Q80X55, Q9CTN4, Q9CVT0
      Related
      ENSMUSP00000022078.6, ENSMUST00000022078.12
      Conserved Domains (3) summary
      smart00225
      Location:421518
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:413515
      BTB; BTB/POZ domain
      cl21455
      Location:34174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      76017656..76092054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517411.5XP_006517474.1  rho-related BTB domain-containing protein 3 isoform X2

      Conserved Domains (4) summary
      cd18357
      Location:236393
      BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18532
      Location:471553
      BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cl38908
      Location:410461
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl38936
      Location:34174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_036158195.1XP_036014088.1  rho-related BTB domain-containing protein 3 isoform X5

      Conserved Domains (3) summary
      cd18357
      Location:42199
      BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18360
      Location:216325
      BTB2_POZ_RHOBTB3; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18532
      Location:335417
      BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
    3. XM_011244574.3XP_011242876.1  rho-related BTB domain-containing protein 3 isoform X4

      Conserved Domains (3) summary
      cd18357
      Location:102259
      BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18360
      Location:276385
      BTB2_POZ_RHOBTB3; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18532
      Location:395477
      BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
    4. XM_011244573.3XP_011242875.1  rho-related BTB domain-containing protein 3 isoform X3

      Conserved Domains (3) summary
      cd18357
      Location:140297
      BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18360
      Location:314423
      BTB2_POZ_RHOBTB3; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
      cd18532
      Location:433515
      BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)