5PTase12 Endonuclease/exonuclease/phosphatase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: 5PTase12
Official Full Name: Endonuclease/exonuclease/phosphatase family protein
Primary source: TAIR:AT2G43900
Locus tag: AT2G43900
See related: Araport:AT2G43900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F6E13.3; inositol-polyphosphate 5-phosphatase 12
Summary: Encodes a 5-inositol-phosphate phosphatase, that, in vitro, shows activity against IP(1,4,5).
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Genomic context

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See 5PTase12 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 11

Sequence:: Chromosome: 2; NC_003071.7 (18178588..18184089, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The increase in the levels of Ins(1,4,5)P(3)/Ca(2+) caused by deficiency of inositol polyphosphate 5-phosphatases is sufficient to break pollen dormancy and to trigger early germination. [5PT12]
Title: Inositol polyphosphate 5-phosphatase-controlled Ins(1,4,5)P3/Ca2+ is crucial for maintaining pollen dormancy and regulating early germination of pollen.

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Pathways from PubChem

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General gene information

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NM_001337064.1

Supported by ESTs:

NM_129952.7

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables inositol-1,4,5-trisphosphate 5-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within inositol phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Endonuclease/exonuclease/phosphatase family protein

NP_181918.4

Endonuclease/exonuclease/phosphatase family protein; FUNCTIONS IN: inositol-polyphosphate 5-phosphatase activity, inositol or phosphatidylinositol phosphatase activity; INVOLVED IN: biological_process unknown; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: sperm cell, male gametophyte, flower, cultured cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), Inositol polyphosphate related phosphatase (InterPro:IPR000300), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: Endonuclease/exonuclease/phosphatase family protein (TAIR:AT1G05630.2); Has 8064 Blast hits to 7016 proteins in 490 species: Archae - 18; Bacteria - 518; Metazoa - 2458; Fungi - 805; Plants - 729; Viruses - 32; Other Eukaryotes - 3504 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

18178588..18184089 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129952.7 → NP_181918.4 Endonuclease/exonuclease/phosphatase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181918.4

Status: REVIEWED

UniProtKB/Swiss-Prot

F4IS64, O80560, Q712G3

UniProtKB/TrEMBL

A0A7G2EDJ1

Conserved Domains (4) summary

cd09074
Location:576 → 923

INPP5c; Catalytic domain of inositol polyphosphate 5-phosphatases

COG2319
Location:215 → 379

WD40; WD40 repeat [General function prediction only]

sd00039
Location:219 → 264

7WD40; WD40 repeat [structural motif]

cl02567
Location:215 → 547

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001337064.1 → NP_001323432.1 Endonuclease/exonuclease/phosphatase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AX44, A0A7G2EDJ1

Conserved Domains (3) summary

cd09074
Location:576 → 923

INPP5c; Catalytic domain of inositol polyphosphate 5-phosphatases

NF033845
Location:1238 → 1346

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

cl29593
Location:215 → 547

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...