PCNA2 proliferating cell nuclear antigen 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PCNA2
Official Full Name: proliferating cell nuclear antigen 2
Primary source: TAIR:AT2G29570
Locus tag: AT2G29570
See related: Araport:AT2G29570
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: A. THALIANA PROLIFERATING CELL NUCLEAR ANTIGEN 2; ATPCNA2; F16P2.5; F16P2_5; proliferating cell nuclear antigen 2
Summary: Functionally interacts with POLH to repair DNA damaged by UVB damage. May be sumoylated.
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Genomic context

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See PCNA2 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 4

Sequence:: Chromosome: 2; NC_003071.7 (12649906..12651753, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A crystallization and preliminary X-ray diffraction study of the Arabidopsis thaliana proliferating cell nuclear antigen (PCNA2) alone and in a complex with a PIP-box peptide from Flap endonuclease 1.
Title: A crystallization and preliminary X-ray diffraction study of the Arabidopsis thaliana proliferating cell nuclear antigen (PCNA2) alone and in a complex with a PIP-box peptide from Flap endonuclease 1.
Arabidopsis PCNA1 and PCNA2 differ in their efficiency for ubiquitination and sumoylation, leading to their differential responses to DNA damage in yeast cells.
Title: Similarities and differences between Arabidopsis PCNA1 and PCNA2 in complementing the yeast DNA damage tolerance defect.
PCNA1 and PCNA2 may cooperate in planta by forming homo- and heterotrimeric rings.
Title: Arabidopsis thaliana: proliferating cell nuclear antigen 1 and 2 possibly form homo- and hetero-trimeric complexes in the plant cell.
PCNA2 but not PCNA1 increases the selectivity for dCTP incorporation opposite 8-Oxo-G by DNA Pol lambda.
Title: Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase λ and proliferating cell nuclear antigen 2.
atomic resolution crystal structures of the PCNA1 and PCNA2 complexed with the C-terminal segment of human p21; structures demonstrated that PCNA1 & 2 adopt identical architectures
Title: Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment.
AtPolH confers UV resistance by interacting with PNCA2 and catalyzing translesion synthesis.
Title: Arabidopsis thaliana Y-family DNA polymerase eta catalyses translesion synthesis and interacts functionally with PCNA2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_128510.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA polymerase processivity factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within error-prone translesion synthesis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA replication	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: proliferating cell nuclear antigen 2

NP_180517.1

proliferating cell nuclear antigen 2 (PCNA2); FUNCTIONS IN: DNA binding, DNA polymerase processivity factor activity; INVOLVED IN: regulation of DNA replication, error-prone translesion synthesis; LOCATED IN: PCNA complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Proliferating cell nuclear antigen, PCNA (InterPro:IPR000730), Proliferating cell nuclear antigen, PCNA, C-terminal (InterPro:IPR022649), Proliferating cell nuclear antigen, PCNA, conserved site (InterPro:IPR022659), Proliferating cell nuclear antigen, PCNA, N-terminal (InterPro:IPR022648); BEST Arabidopsis thaliana protein match is: proliferating cellular nuclear antigen 1 (TAIR:AT1G07370.1); Has 1860 Blast hits to 1848 proteins in 457 species: Archae - 391; Bacteria - 0; Metazoa - 314; Fungi - 169; Plants - 159; Viruses - 73; Other Eukaryotes - 754 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

12649906..12651753 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128510.3 → NP_180517.1 proliferating cell nuclear antigen 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180517.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0JQ96, Q9ZW35

UniProtKB/TrEMBL

A0A178VSR5, A0A5S9X2G4, A0A6B7JDQ4

Conserved Domains (1) summary

PLN00057
Location:1 → 263

PLN00057; proliferating cell nuclear antigen; Provisional