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    TIM17-2 translocase inner membrane subunit 17-2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818317, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TIM17-2
    Official Full Name
    translocase inner membrane subunit 17-2
    Primary source
    TAIR:AT2G37410
    Locus tag
    AT2G37410
    See related
    Araport:AT2G37410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATTIM17-2; F3G5.20; F3G5_20; TIM17; translocase inner membrane subunit 17-2; TRANSLOCASE OF THE INNER MEMBRANE 17
    Summary
    Mitochondrial inner membrane translocase. Together with AtTIM17-1, TIM17-2 has a long C-terminal extension not present in other TIMs. The extension is located in the outer membrane and so TIM17-2 links the inner and outer mitochondrial membranes. The C-terminal region is essential for protein import into mitochondria via the general import pathway but is not necessary for import via the carrier pathway.
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    Genomic context

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    See TIM17-2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (15697810..15699354, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Chloroplast-targeted copper chaperone protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ATP binding microtubule motor family protein Neighboring gene C2H2 and C2HC zinc fingers superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C-terminal region of TIM17 links the outer and inner mitochondrial membranes in Arabidopsis and is essential for protein import. Murcha MW, et al. J Biol Chem, 2005 Apr 22. PMID 15722347
    2. The plant i-AAA protease controls the turnover of an essential mitochondrial protein import component. Opalińska M, et al. J Cell Sci, 2018 Jan 29. PMID 28264925
    3. Dual location of the mitochondrial preprotein transporters B14.7 and Tim23-2 in complex I and the TIM17:23 complex in Arabidopsis links mitochondrial activity and biogenesis. Wang Y, et al. Plant Cell, 2012 Jun. PMID 22730406, Free PMC Article
    4. Identification, expression, and import of components 17 and 23 of the inner mitochondrial membrane translocase from Arabidopsis. Murcha MW, et al. Plant Physiol, 2003 Apr. PMID 12692332, Free PMC Article
    5. A transcriptomic and proteomic characterization of the Arabidopsis mitochondrial protein import apparatus and its response to mitochondrial dysfunction. Lister R, et al. Plant Physiol, 2004 Feb. PMID 14730085, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the abundance of the Tim17-2 protein, an essential component of the TIM17:23 translocase (Tim17-2 together with Tim50 and Tim23), is directly controlled by the proteolytic activity of FTSH4.
      Title: The plant i-AAA protease controls the turnover of an essential mitochondrial protein import component.
    2. C-terminal region of AtTIM17-2 is exposed on the outer surface of the outer mitochondrial membrane, is essential for protein import into mitochondria
      Title: The C-terminal region of TIM17 links the outer and inner mitochondrial membranes in Arabidopsis and is essential for protein import.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_129296.4
    NM_201892.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein insertion into mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    translocase inner membrane subunit 17-2
    NP_181277.1
    • translocase inner membrane subunit 17-2 (TIM17-2); FUNCTIONS IN: protein transporter activity, P-P-bond-hydrolysis-driven protein transmembrane transporter activity; INVOLVED IN: protein transport, protein import into mitochondrial inner membrane; LOCATED IN: mitochondrial outer membrane, mitochondrion, mitochondrial inner membrane, mitochondrial inner membrane presequence translocase complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Mitochondrial inner membrane translocase complex, subunit Tim17/22 (InterPro:IPR003397); BEST Arabidopsis thaliana protein match is: translocase inner membrane subunit 17-1 (TAIR:AT1G20350.1); Has 2051 Blast hits to 1654 proteins in 249 species: Archae - 0; Bacteria - 134; Metazoa - 977; Fungi - 256; Plants - 141; Viruses - 2; Other Eukaryotes - 541 (source: NCBI BLink).
    NP_973621.1
    • translocase inner membrane subunit 17-2 (TIM17-2); FUNCTIONS IN: protein transporter activity, P-P-bond-hydrolysis-driven protein transmembrane transporter activity; INVOLVED IN: protein transport, protein import into mitochondrial inner membrane; LOCATED IN: mitochondrial outer membrane, mitochondrion, mitochondrial inner membrane, mitochondrial inner membrane presequence translocase complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Mitochondrial inner membrane translocase complex, subunit Tim17/22 (InterPro:IPR003397); BEST Arabidopsis thaliana protein match is: translocase inner membrane subunit 17-1 (TAIR:AT1G20350.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15697810..15699354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129296.4 → NP_181277.1  translocase inner membrane subunit 17-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181277.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SP35, Q9ZUS5
      UniProtKB/TrEMBL
      Q6S710
      Conserved Domains (1) summary
      cl02381
      Location:7 → 147
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    2. NM_201892.1 → NP_973621.1  translocase inner membrane subunit 17-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973621.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SP35, Q9ZUS5
      UniProtKB/TrEMBL
      Q6S710
      Conserved Domains (1) summary
      cl02381
      Location:7 → 147
      Tim17; Tim17/Tim22/Tim23/Pmp24 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SP35.2

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