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    IMPA-4 importin alpha isoform 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837448, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IMPA-4
    Official Full Name
    importin alpha isoform 4
    Primary source
    TAIR:AT1G09270
    Locus tag
    AT1G09270
    See related
    Araport:AT1G09270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    importin alpha isoform 4; T12M4.2; T12M4_2
    Summary
    Protein interacts with Agrobacterium proteins VirD2 and VirE2.
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    Genomic context

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    See IMPA-4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (2994331..2998222)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene rhodanese-like domain protein Neighboring gene uncharacterized protein Neighboring gene Metallopeptidase M24 family protein Neighboring gene plant/protein (Protein of unknown function, DUF538) Neighboring gene agenet domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IMPa-4, an Arabidopsis importin alpha isoform, is preferentially involved in agrobacterium-mediated plant transformation. Bhattacharjee S, et al. Plant Cell, 2008 Oct. PMID 18836040, Free PMC Article
    2. Telomerase Interaction Partners-Insight from Plants. Fulnečková J, et al. Int J Mol Sci, 2021 Dec 29. PMID 35008793, Free PMC Article
    3. Tandem affinity purification of AtTERT reveals putative interaction partners of plant telomerase in vivo. Majerská J, et al. Protoplasma, 2017 Jul. PMID 27853871
    4. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article
    5. Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Tamura K, et al. Plant Cell, 2010 Dec. PMID 21189294, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of the importin IMPa-4 inhibits Agrobacterium mediated transformation.
      Title: IMPa-4, an Arabidopsis importin alpha isoform, is preferentially involved in agrobacterium-mediated plant transformation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035934.2
    NM_100797.6
    NM_179292.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within host response to induction by symbiont of tumor, nodule or growth in host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within symbiont intracellular protein transport in host IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    importin alpha isoform 4
    NP_001031011.1
    • importin alpha isoform 4 (IMPA-4); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, symbiont intracellular protein transport in host, host response to induction by symbiont of tumor, nodule or growth in host; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 1 (TAIR:AT3G06720.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_172398.1
    • importin alpha isoform 4 (IMPA-4); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, symbiont intracellular protein transport in host, host response to induction by symbiont of tumor, nodule or growth in host; LOCATED IN: nucleus, nuclear pore, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 1 (TAIR:AT3G06720.2); Has 4272 Blast hits to 3104 proteins in 282 species: Archae - 2; Bacteria - 6; Metazoa - 1653; Fungi - 615; Plants - 1226; Viruses - 0; Other Eukaryotes - 770 (source: NCBI BLink).
    NP_849623.1
    • importin alpha isoform 4 (IMPA-4); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, symbiont intracellular protein transport in host, host response to induction by symbiont of tumor, nodule or growth in host; LOCATED IN: nucleus, nuclear pore, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 1 (TAIR:AT3G06720.2); Has 4272 Blast hits to 3104 proteins in 282 species: Archae - 2; Bacteria - 6; Metazoa - 1653; Fungi - 615; Plants - 1226; Viruses - 0; Other Eukaryotes - 770 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2994331..2998222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100797.6 → NP_172398.1  importin alpha isoform 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172398.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HZG6, O49602, O80480, Q94KD4
      UniProtKB/TrEMBL
      A0A178WMY7, A0A5S9TEM2
      Conserved Domains (2) summary
      COG5064
      Location:17 → 536
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:118 → 150
      ARM; armadillo repeat [structural motif]

    2. NM_179292.3 → NP_849623.1  importin alpha isoform 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849623.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HZG6, O49602, O80480, Q94KD4
      UniProtKB/TrEMBL
      A0A178WMY7, A0A5S9TEM2
      Conserved Domains (2) summary
      COG5064
      Location:17 → 536
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:118 → 150
      ARM; armadillo repeat [structural motif]

    3. NM_001035934.2 → NP_001031011.1  importin alpha isoform 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031011.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9TEM2
      Conserved Domains (4) summary
      cd00020
      Location:34 → 155
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:2 → 19
      IBB; Importin beta binding domain
      pfam13646
      Location:42 → 151
      HEAT_2; HEAT repeats
      sd00043
      Location:36 → 68
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80480.1

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