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    MC4 metacaspase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844272, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MC4
    Official Full Name
    metacaspase 4
    Primary source
    TAIR:AT1G79340
    Locus tag
    AT1G79340
    See related
    Araport:AT1G79340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMC4; AtMCP2d; MCP2d; metacaspase 2d; metacaspase 4; YUP8H12R.4; YUP8H12R_4
    Summary
    Encodes MCP2d, the predominant and constitutively expressed member of type II metacaspases (MCPs). MCP2d plays a positive regulatory role in biotic and abiotic stress-induced programmed cell death (PCD). Arabidopsis contains three type I MCP genes (MCP1a-c) and six type II MCP genes (MCP2a#Aeif): AtMCP1a/At5g64240, AtMCP1b/At1g02170, AtMCP1c/At4g25110, AtMCP2a/At1g79310, AtMCP2b/At1g79330, AtMCP2c/At1g79320, AtMCP2d/At1g79340, AtMCP2e/At1g16420, AtMCP2f/At5g04200.
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    Genomic context

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    See MC4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (29842587..29844638)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene metacaspase 6 Neighboring gene miscRNA Neighboring gene metacaspase 5 Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene organic cation/carnitine transporter 2 Neighboring gene cytochrome P450, family 79, subfamily C, polypeptide 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis metacaspase 2d is a positive mediator of cell death induced during biotic and abiotic stresses. Watanabe N, et al. Plant J, 2011 Jun. PMID 21395887
    2. Calcium-dependent activation and autolysis of Arabidopsis metacaspase 2d. Watanabe N, et al. J Biol Chem, 2011 Mar 25. PMID 21209078, Free PMC Article
    3. Damage on plants activates Ca(2+)-dependent metacaspases for release of immunomodulatory peptides. Hander T, et al. Science, 2019 Mar 22. PMID 30898901
    4. The AtMC4 regulates the stem cell homeostasis in Arabidopsis by catalyzing the cleavage of AtLa1 protein in response to environmental hazards. Huang Y, et al. Plant Sci, 2018 Jan. PMID 29241568
    5. Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine. Vercammen D, et al. J Biol Chem, 2004 Oct 29. PMID 15326173

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study demonstrates that upon damage, both at the tissue and single-cell levels, the cysteine protease METACASPASE4 (MC4) is instantly and spatiotemporally activated by binding high levels of Ca(2+) and is necessary and sufficient for Pep1 maturation.
      Title: Damage on plants activates Ca(2+)-dependent metacaspases for release of immunomodulatory peptides.
    2. The AtMC4 protein regulates stem cell homeostasis by catalyzing the cleavage of AtLa1 protein in response to environmental hazards.
      Title: The AtMC4 regulates the stem cell homeostasis in Arabidopsis by catalyzing the cleavage of AtLa1 protein in response to environmental hazards.
    3. AtMCP2d plays a positive regulatory role in biotic and abiotic stress-induced programmed cell death. [MCP2d]
      Title: Arabidopsis metacaspase 2d is a positive mediator of cell death induced during biotic and abiotic stresses.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_106582.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of programmed cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autoprocessing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    metacaspase 4
    NP_178052.1
    • metacaspase 4 (MC4); FUNCTIONS IN: cysteine-type peptidase activity; INVOLVED IN: proteolysis; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C14, caspase catalytic (InterPro:IPR011600); BEST Arabidopsis thaliana protein match is: metacaspase 5 (TAIR:AT1G79330.1); Has 1195 Blast hits to 1161 proteins in 285 species: Archae - 6; Bacteria - 340; Metazoa - 3; Fungi - 271; Plants - 332; Viruses - 0; Other Eukaryotes - 243 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29842587..29844638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106582.4 → NP_178052.1  metacaspase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178052.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64517, Q7XBI1
      UniProtKB/TrEMBL
      A0A178WK95, A0A5S9WVT4, A0A654EVH1
      Conserved Domains (1) summary
      pfam00656
      Location:3 → 156
      Peptidase_C14; Caspase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64517.1

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