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    WAK1 cell wall-associated kinase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838721, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WAK1
    Official Full Name
    cell wall-associated kinase
    Primary source
    TAIR:AT1G21250
    Locus tag
    AT1G21250
    See related
    Araport:AT1G21250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtWAK1; cell wall-associated kinase; cell wall-associated kinase 1; F16F4.6; F16F4_6; PRO25; SERINE THREONINE KINASE
    Summary
    cell wall-associated kinase, may function as a signaling receptor of extracellular matrix component such as oligogalacturonides.
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    Genomic context

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    See WAK1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (7439171..7442113)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene wall associated kinase 3 Neighboring gene Protein kinase superfamily protein Neighboring gene pseudo Neighboring gene wall-associated kinase 2 Neighboring gene Copia-like polyprotein/retrotransposon

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides. Brutus A, et al. Proc Natl Acad Sci U S A, 2010 May 18. PMID 20439716, Free PMC Article
    2. In vitro characterization of the homogalacturonan-binding domain of the wall-associated kinase WAK1 using site-directed mutagenesis. Decreux A, et al. Phytochemistry, 2006 Jun. PMID 16631829
    3. Wall-associated kinase WAK1 interacts with cell wall pectins in a calcium-induced conformation. Decreux A, et al. Plant Cell Physiol, 2005 Feb. PMID 15769808
    4. WAKs: cell wall-associated kinases linking the cytoplasm to the extracellular matrix. Anderson CM, et al. Plant Mol Biol, 2001 Sep. PMID 11554472
    5. A cell wall-associated, receptor-like protein kinase. He ZH, et al. J Biol Chem, 1996 Aug 16. PMID 8702686

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a positive function of WAK1 and a negative function of GRP-3 and KAPP in the oligogalacturonides-triggered expression of defence genes and the production of an oxidative burst, is reported.
      Title: GRP-3 and KAPP, encoding interactors of WAK1, negatively affect defense responses induced by oligogalacturonides and local response to wounding.
    2. we also show that grp3-1 exhibits an enhanced Aluminum (Al) tolerance, a feature also described in AtWAK1 overexpressing plants. Together, these results implicate AtGRP3 function root size determination during development and in Al stress.
      Title: AtGRP3 Is Implicated in Root Size and Aluminum Response Pathways in Arabidopsis.
    3. The plant wall-associated kinase 1 (WAK1) functions as a oligogalacturonide receptor.
      Title: A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides.
    4. non-covalent link between WAK(67-254) and cell wall pectins is discussed in terms of cell elongation, cell differentiation and host-pathogen interactions
      Title: Wall-associated kinase WAK1 interacts with cell wall pectins in a calcium-induced conformation.
    5. Characterization of the homogalacturonan-binding domain of WAK1.
      Title: In vitro characterization of the homogalacturonan-binding domain of the wall-associated kinase WAK1 using site-directed mutagenesis.
    6. WAKs may thus provide a molecular mechanism linking cell wall sensing (via pectin attachment) to regulation of solute metabolism.
      Title: An Arabidopsis cell wall-associated kinase required for invertase activity and cell growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101978.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables polysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell surface receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plant-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell wall-associated kinase
    NP_564137.1
    • cell wall-associated kinase (WAK1); FUNCTIONS IN: kinase activity; INVOLVED IN: cell surface receptor linked signaling pathway, response to virus, defense response to fungus, response to salicylic acid stimulus; LOCATED IN: plasma membrane, vacuole, plant-type cell wall; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: EGF-like calcium-binding (InterPro:IPR001881), EGF-like, type 3 (InterPro:IPR000742), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EGF-like calcium-binding, conserved site (InterPro:IPR018097), EGF-type aspartate/asparagine hydroxylation site (InterPro:IPR000152), EGF calcium-binding (InterPro:IPR013091), EGF-like (InterPro:IPR006210); BEST Arabidopsis thaliana protein match is: wall associated kinase 3 (TAIR:AT1G21240.1); Has 130372 Blast hits to 120319 proteins in 4569 species: Archae - 123; Bacteria - 13482; Metazoa - 56283; Fungi - 9380; Plants - 33196; Viruses - 438; Other Eukaryotes - 17470 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7439171..7442113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101978.5 → NP_564137.1  cell wall-associated kinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564137.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81820, Q39191, Q56WT2, Q9LMP0
      UniProtKB/TrEMBL
      A0A5S9VDS8
      Conserved Domains (3) summary
      smart00179
      Location:282 → 323
      EGF_CA; Calcium-binding EGF-like domain
      cd14066
      Location:415 → 682
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam13947
      Location:32 → 88
      GUB_WAK_bind; Wall-associated receptor kinase galacturonan-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39191.2

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