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    CAM9 calmodulin 9 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824355, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAM9
    Official Full Name
    calmodulin 9
    Primary source
    TAIR:AT3G51920
    Locus tag
    AT3G51920
    See related
    Araport:AT3G51920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCML9; calmodulin 9; CALMODULIN 9; CALMODULIN LIKE PROTEIN 9; CML9
    Summary
    encodes a divergent member of calmodulin, which is an EF-hand family of Ca2+-binding proteins. This gene is expressed in leaves, flowers and siliques. The gene functionally complements yeast calmodulin 1 (CAM1) but only when selected against the plasmid harboring wild-type yeast sequences. Also the protein does not form formed a complex with a basic amphiphilic helical peptide in the presence of Ca2+ in vitro. Authors suggest that this gene may represent a Ca2+-binding sensor protein that interacts with a more limited set of target proteins than do more conventional CaM isoforms. Mutations in this gene alter plant responses to abiotic stress and abscisic acid.
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    Genomic context

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    See CAM9 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (19267951..19269658, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene sulfate transporter 3;1 Neighboring gene heat shock transcription factor A7A Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene oxidoreductase/transition metal ion-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Herbivory-responsive calmodulin-like protein CML9 does not guide jasmonate-mediated defenses in Arabidopsis thaliana. Heyer M, et al. PLoS One, 2018. PMID 29768484, Free PMC Article
    2. CML9, a multifunctional Arabidopsis thaliana calmodulin-like protein involved in stress responses and plant growth? Leba LJ, et al. Plant Signal Behav, 2012 Sep 1. PMID 22899061, Free PMC Article
    3. CML9, an Arabidopsis calmodulin-like protein, contributes to plant innate immunity through a flagellin-dependent signalling pathway. Leba LJ, et al. Plant J, 2012 Sep. PMID 22563930
    4. Mutations in AtCML9, a calmodulin-like protein from Arabidopsis thaliana, alter plant responses to abiotic stress and abscisic acid. Magnan F, et al. Plant J, 2008 Nov. PMID 18643966
    5. Respective contribution of CML8 and CML9, two arabidopsis calmodulin-like proteins, to plant stress responses. Zhu X, et al. Plant Signal Behav, 2017 May 4. PMID 28471263, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. might be a regulator involved only in the defense against biotrophic pathogens, independent of jasmonates
      Title: Herbivory-responsive calmodulin-like protein CML9 does not guide jasmonate-mediated defenses in Arabidopsis thaliana.
    2. Data showed that CML8, an Arabidopsis calcium sensor belonging to the calmodulin-like (CML) protein family, promotes plant immunity against the phytopathogenic bacteria Pseudomonas syringae pv tomato (strain DC3000). Interestingly, other CML proteins such as CML9 were also reported to contribute to plant immunity using the same pathosystem
      Title: Respective contribution of CML8 and CML9, two arabidopsis calmodulin-like proteins, to plant stress responses.
    3. CML9 participates in plant innate immunity.
      Title: CML9, an Arabidopsis calmodulin-like protein, contributes to plant innate immunity through a flagellin-dependent signalling pathway.
    4. CML9, a calmodulin-like protein that appears to be involved in plant responses to both biotic and abiotic stress. [CML9]
      Title: CML9, a multifunctional Arabidopsis thaliana calmodulin-like protein involved in stress responses and plant growth?
    5. These findings suggest that binding of PRR2 to CML9 may be an important mechanism to modulate the physiological role of this transcription factor in plants.
      Title: Interaction of a plant pseudo-response regulator with a calmodulin-like protein.
    6. CML9 alters plant responses to abiotic stress, such as salt stress, and abscisic acid.
      Title: Mutations in AtCML9, a calmodulin-like protein from Arabidopsis thaliana, alter plant responses to abiotic stress and abscisic acid.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115051.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within detection of calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin 9
    NP_190760.1
    • calmodulin 9 (CAM9); FUNCTIONS IN: calcium ion binding; INVOLVED IN: response to salt stress, response to water deprivation, detection of calcium ion, calcium-mediated signaling, response to abscisic acid stimulus; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 1 (TAIR:AT5G37780.1); Has 22298 Blast hits to 16833 proteins in 1534 species: Archae - 0; Bacteria - 90; Metazoa - 8769; Fungi - 5904; Plants - 4665; Viruses - 0; Other Eukaryotes - 2870 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19267951..19269658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115051.3 → NP_190760.1  calmodulin 9 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190760.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S744
      UniProtKB/TrEMBL
      A0A7G2ES29
      Conserved Domains (2) summary
      PTZ00184
      Location:1 → 148
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:85 → 146
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S744.1

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