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    COPT1 copper transporter 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836020, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COPT1
    Official Full Name
    copper transporter 1
    Primary source
    TAIR:AT5G59030
    Locus tag
    AT5G59030
    See related
    Araport:AT5G59030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    copper transporter 1; K19M22.24
    Summary
    encodes a putative copper transport protein that contains copper-binding motif and functionally complements in copper-transport defective yeast strains
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    Genomic context

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    See COPT1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (23833493..23834745, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene kinase with tetratricopeptide repeat domain-containing protein Neighboring gene ncRNA Neighboring gene hepatocyte growth factor activator, putative (DUF3527) Neighboring gene copper transporter 3 Neighboring gene G patch domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Copper and ectopic expression of the Arabidopsis transport protein COPT1 alter iron homeostasis in rice (Oryza sativa L.). Andrés-Bordería A, et al. Plant Mol Biol, 2017 Sep. PMID 28631167
    2. Calcium- and potassium-permeable plasma membrane transporters are activated by copper in Arabidopsis root tips: linking copper transport with cytosolic hydroxyl radical production. Rodrigo-Moreno A, et al. Plant Cell Environ, 2013 Apr. PMID 23046313
    3. The Arabidopsis copper transporter COPT1 functions in root elongation and pollen development. Sancenón V, et al. J Biol Chem, 2004 Apr 9. PMID 14726516
    4. Deregulated copper transport affects Arabidopsis development especially in the absence of environmental cycles. Andrés-Colás N, et al. Plant Physiol, 2010 May. PMID 20335405, Free PMC Article
    5. Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue. Kampfenkel K, et al. J Biol Chem, 1995 Nov 24. PMID 7499355

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis COPT1 overexpression (C1 (OE) ) in rice causes root shortening in high copper conditions and under iron deficiency.
      Title: Copper and ectopic expression of the Arabidopsis transport protein COPT1 alter iron homeostasis in rice (Oryza sativa L.).
    2. Data indicate that cadmium (Cd) elicits SPL7-dependent copper (Cu) deficiency responses by altering expression of COPT1, COPT2, COPT6, CSD1, CSD2, miRNA398 b/c precursors and FSD1.
      Title: The CTR/COPT-dependent copper uptake and SPL7-dependent copper deficiency responses are required for basal cadmium tolerance in A. thaliana.
    3. Col-0, high-affinity copper transporter COPT1-overexpressing (C1(OE)) seedlings and T-DNA COPT1 insertion mutant (copt1) differ in their copper-transport activity. C1(OE) showed a fivefold higher Cu-induced K(+) efflux at the root tip compared with Col-0.
      Title: Calcium- and potassium-permeable plasma membrane transporters are activated by copper in Arabidopsis root tips: linking copper transport with cytosolic hydroxyl radical production.
    4. overexpressing transgenic plants exhibit increased endogenous copper levels and are sensitive to the copper in the growth medium
      Title: Deregulated copper transport affects Arabidopsis development especially in the absence of environmental cycles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_125293.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables copper ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within copper ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen sperm cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    copper transporter 1
    NP_200711.1
    • copper transporter 1 (COPT1); CONTAINS InterPro DOMAIN/s: Ctr copper transporter (InterPro:IPR007274); BEST Arabidopsis thaliana protein match is: Ctr copper transporter family (TAIR:AT2G26975.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23833493..23834745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125293.4 → NP_200711.1  copper transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200711.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39065, Q547P9
      UniProtKB/TrEMBL
      A0A178UQV5, A0A654GCD4
      Conserved Domains (1) summary
      pfam04145
      Location:45 → 146
      Ctr; Ctr copper transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39065.2

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