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    Npm2 nucleophosmin/nucleoplasmin 2 [ Mus musculus (house mouse) ]

    Gene ID: 328440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Npm2provided by MGI
    Official Full Name
    nucleophosmin/nucleoplasmin 2provided by MGI
    Primary source
    MGI:MGI:1890811
    See related
    Ensembl:ENSMUSG00000047911 AllianceGenome:MGI:1890811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables chromatin binding activity. Acts upstream of or within chromatin remodeling. Located in nucleus. Is expressed in early conceptus and ovary. Orthologous to human NPM2 (nucleophosmin/nucleoplasmin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 2.6), ovary adult (RPKM 1.4) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Npm2 in Genome Data Viewer
    Location:
    14 D2; 14 36.42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70884736..70896694, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70647296..70661802, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene dematin actin binding protein Neighboring gene STARR-seq mESC enhancer starr_37085 Neighboring gene predicted gene, 38605 Neighboring gene fibroblast growth factor 17 Neighboring gene predicted gene, 52133 Neighboring gene exportin 7 Neighboring gene STARR-seq mESC enhancer starr_37090 Neighboring gene PCNA-associated factor pseudogene Neighboring gene docking protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reconstitution of the oocyte nucleolus in mice through a single nucleolar protein, NPM2. Ogushi S, et al. J Cell Sci, 2017 Jul 15. PMID 28600324, Free PMC Article
    2. Major chromatin remodeling in the germinal vesicle (GV) of mammalian oocytes is dispensable for global transcriptional silencing but required for centromeric heterochromatin function. De La Fuente R, et al. Dev Biol, 2004 Nov 15. PMID 15501230
    3. Proteomic profiling of murine oocyte maturation. Vitale AM, et al. Mol Reprod Dev, 2007 May. PMID 17044029
    4. Involvement of mouse nucleoplasmin 2 in the decondensation of sperm chromatin after fertilization. Inoue A, et al. Biol Reprod, 2011 Jul. PMID 21415138
    5. Role of the nucleoplasmin 2 C-terminal domain in the formation of nucleolus-like bodies in mouse oocytes. Inoue A, et al. FASEB J, 2010 Feb. PMID 19805576

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings demonstrate that the NPM2-based oocyte nucleolus is an essential platform for parental chromatin organization in early embryonic development.
      Title: Reconstitution of the oocyte nucleolus in mice through a single nucleolar protein, NPM2.
    2. involved in sperm chromatin remodeling
      Title: Involvement of mouse nucleoplasmin 2 in the decondensation of sperm chromatin after fertilization.
    3. NPM2 targeting of nucleolus-like bodies (NLBs) is regulated by the K-rich motif and is essential for the formation of NLBs.
      Title: Role of the nucleoplasmin 2 C-terminal domain in the formation of nucleolus-like bodies in mouse oocytes.
    4. The highest Npm2 mRNA levels were detected in oocytes in the pre-antral follicle stage.
      Title: Quantification of oocyte-specific transcripts in follicle-enclosed oocytes during antral development and maturation in vitro.
    5. Promoter activities of three mouse maternal genes (H1oo, Npm2, and Zar1) in oocytes and pre-implantation embryos, and examined the promoters and to obttain the best promoter for oocytte gene expression.
      Title: Cis-acting elements (E-box and NBE) in the promoter region of three maternal genes (Histone H1oo, Nucleoplasmin 2, and Zygote Arrest 1) are required for oocyte-specific gene expression in the mouse.
    6. Npm2 is a maternal effect gene critical for nuclear and nucleolar organization and embryonic development
      Title: Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123506, MGC123507

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP-dependent protein-DNA complex displacement activity TAS
    Traceable Author Statement
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blastocyst development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of meiotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of exit from mitosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of exit from mitosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in single fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleoplasmin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412003.1 → NP_001398932.1  nucleoplasmin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154563
      UniProtKB/Swiss-Prot
      Q80W85, Q8BW23
      UniProtKB/TrEMBL
      Q3SXW7

    2. NM_001412004.1 → NP_001398933.1  nucleoplasmin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154563
      UniProtKB/Swiss-Prot
      Q80W85, Q8BW23
      UniProtKB/TrEMBL
      Q3SXW7

    3. NM_001412005.1 → NP_001398934.1  nucleoplasmin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154563
      UniProtKB/Swiss-Prot
      Q80W85, Q8BW23
      UniProtKB/TrEMBL
      Q3SXW7
      Related
      ENSMUSP00000154427.2, ENSMUST00000228473.2

    4. NM_001425911.1 → NP_001412840.1  nucleoplasmin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154563

    5. NM_181345.4 → NP_851990.2  nucleoplasmin-2 isoform 1

      See identical proteins and their annotated locations for NP_851990.2

      Status: VALIDATED

      Source sequence(s)
      AC154563
      Consensus CDS
      CCDS27261.1
      UniProtKB/Swiss-Prot
      Q80W85, Q8BW23
      UniProtKB/TrEMBL
      Q3SXW7
      Related
      ENSMUSP00000057365.5, ENSMUST00000062629.5
      Conserved Domains (1) summary
      pfam03066
      Location:18 → 116
      Nucleoplasmin; Nucleoplasmin/nucleophosmin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70884736..70896694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W85.1 GenPept UniProtKB/Swiss-Prot:Q80W85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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