Stx16 syntaxin 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stx16provided by MGI
Official Full Name: syntaxin 16provided by MGI
Primary source: MGI:MGI:1923396
See related: Ensembl:ENSMUSG00000027522 AllianceGenome:MGI:1923396
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Syn16; 4930401D03; 5430410K23Rik; 6330500A18Rik
Summary: Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in several processes, including endosomal transport; vesicle docking; and vesicle fusion. Located in Golgi apparatus. Is expressed in several structures, including central nervous system; connective tissue; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in pseudohypoparathyroidism type IB. Orthologous to human STX16 (syntaxin 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 23.8), CNS E11.5 (RPKM 23.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 97.85 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (173918052..173941564)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (174076260..174099771)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syntaxin 16 may thus play a role in neurite outgrowth and perhaps other specific dendritic anterograde/retrograde traffic.
Title: Syntaxin 16 is enriched in neuronal dendrites and may have a role in neurite outgrowth.
Mice genetically altered to carry the equivalent of STX16del4-6 contributing to pseudohypoparathyroidism type 1b.
Title: Lack of Gnas epigenetic changes and pseudohypoparathyroidism type Ib in mice with targeted disruption of syntaxin-16.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW553605 (e-PCR)
- UniSTS:178787

AI648908 (e-PCR)
- UniSTS:164196

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNAP receptor activity	ISO Inferred from Sequence Orthology more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IEA Inferred from Electronic Annotation more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	IEA Inferred from Electronic Annotation more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna	IEA Inferred from Electronic Annotation more info
located_in Golgi cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: syntaxin-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102423.1 → NP_001095893.1 syntaxin-16 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

BC095989, BP763202, BY122006, CX123636

UniProtKB/TrEMBL

Q0VGN4

Conserved Domains (2) summary

cd15845
Location:230 → 288

SNARE_syntaxin16; SNARE motif of syntaxin 16

cl00143
Location:76 → 190

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
NM_001102424.1 → NP_001095894.1 syntaxin-16 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

BC094436, BC095989, BP763202, BY122006

UniProtKB/TrEMBL

Q0VGN4

Conserved Domains (2) summary

cd15845
Location:217 → 275

SNARE_syntaxin16; SNARE motif of syntaxin 16

cl00143
Location:63 → 177

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
NM_001102425.1 → NP_001095895.1 syntaxin-16 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice junction and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

BC095989, BP763202, BY125296

UniProtKB/TrEMBL

Q0VGN4

Conserved Domains (2) summary

cd15845
Location:213 → 271

SNARE_syntaxin16; SNARE motif of syntaxin 16

cl00143
Location:59 → 173

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
NM_001363029.1 → NP_001349958.1 syntaxin-16 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AL669896

UniProtKB/TrEMBL

F7CJY7

Related

ENSMUSP00000116618.2, ENSMUST00000156054.2

Conserved Domains (2) summary

cl22856
Location:217 → 244

SNARE; SNARE motif

cl26014
Location:73 → 254

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
NM_001363030.1 → NP_001349959.1 syntaxin-16 isoform f

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AK029571, AL669896

UniProtKB/TrEMBL

Q0VGN4, Q8C0W8

Conserved Domains (2) summary

COG5325
Location:20 → 249

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15845
Location:181 → 239

SNARE_syntaxin16; SNARE motif of syntaxin 16
NM_001363031.1 → NP_001349960.1 syntaxin-16 isoform g

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (g) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AL669896

Conserved Domains (2) summary

COG5325
Location:19 → 186

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15845
Location:118 → 176

SNARE_syntaxin16; SNARE motif of syntaxin 16
NM_172675.4 → NP_766263.2 syntaxin-16 isoform a

See identical proteins and their annotated locations for NP_766263.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

BC095989, BP763202, BY122006

Consensus CDS

CCDS17147.2

UniProtKB/Swiss-Prot

A2ACM7, Q8BVI5

UniProtKB/TrEMBL

Q0VGN4

Related

ENSMUSP00000085218.4, ENSMUST00000087908.10

Conserved Domains (2) summary

cd15845
Location:234 → 292

SNARE_syntaxin16; SNARE motif of syntaxin 16

cl00143
Location:80 → 194

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

RNA

NR_156433.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL669896

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

173918052..173941564

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499440.5 → XP_006499503.1 syntaxin-16 isoform X2

Conserved Domains (2) summary

COG5325
Location:19 → 186

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15845
Location:118 → 176

SNARE_syntaxin16; SNARE motif of syntaxin 16
XM_030250767.2 → XP_030106627.1 syntaxin-16 isoform X2

Conserved Domains (2) summary

COG5325
Location:19 → 186

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15845
Location:118 → 176

SNARE_syntaxin16; SNARE motif of syntaxin 16
XM_030250772.2 → XP_030106632.1 syntaxin-16 isoform X2

Conserved Domains (2) summary

COG5325
Location:19 → 186

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15845
Location:118 → 176

SNARE_syntaxin16; SNARE motif of syntaxin 16
XM_006499437.4 → XP_006499500.1 syntaxin-16 isoform X1

See identical proteins and their annotated locations for XP_006499500.1

UniProtKB/TrEMBL

Q0VGN4, Q8C0W8

Conserved Domains (2) summary

COG5325
Location:20 → 249

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15845
Location:181 → 239

SNARE_syntaxin16; SNARE motif of syntaxin 16
XM_006499439.4 → XP_006499502.1 syntaxin-16 isoform X1

See identical proteins and their annotated locations for XP_006499502.1

UniProtKB/TrEMBL

Q0VGN4, Q8C0W8

Conserved Domains (2) summary

COG5325
Location:20 → 249

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15845
Location:181 → 239

SNARE_syntaxin16; SNARE motif of syntaxin 16
XM_006499436.4 → XP_006499499.1 syntaxin-16 isoform X1

See identical proteins and their annotated locations for XP_006499499.1

UniProtKB/TrEMBL

Q0VGN4, Q8C0W8

Conserved Domains (2) summary

COG5325
Location:20 → 249

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15845
Location:181 → 239

SNARE_syntaxin16; SNARE motif of syntaxin 16
XM_006499438.4 → XP_006499501.1 syntaxin-16 isoform X1

See identical proteins and their annotated locations for XP_006499501.1

UniProtKB/TrEMBL

Q0VGN4, Q8C0W8

Conserved Domains (2) summary

COG5325
Location:20 → 249

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15845
Location:181 → 239

SNARE_syntaxin16; SNARE motif of syntaxin 16
XM_030250771.1 → XP_030106631.1 syntaxin-16 isoform X2

Conserved Domains (2) summary

COG5325
Location:19 → 186

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15845
Location:118 → 176

SNARE_syntaxin16; SNARE motif of syntaxin 16