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    Pdzk1ip1 PDZK1 interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 67182, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pdzk1ip1provided by MGI
    Official Full Name
    PDZK1 interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1914432
    See related
    Ensembl:ENSMUSG00000028716 AllianceGenome:MGI:1914432
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Map17; 0610007F13Rik; 2700030M23Rik
    Summary
    Predicted to be located in apical plasma membrane. Is expressed in several structures, including central nervous system; dorsal aorta; metanephros; naris; and retina. Orthologous to human PDZK1IP1 (PDZK1 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 657.0), colon adult (RPKM 64.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pdzk1ip1 in Genome Data Viewer
    Location:
    4 D1; 4 52.75 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (114945905..114951091)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115088708..115093894)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52674 Neighboring gene predicted gene, 33786 Neighboring gene T cell acute lymphocytic leukemia 1 Neighboring gene cytochrome P450, family 4, subfamily x, polypeptide 1 Neighboring gene cytochrome P450, family 4, subfamily x, polypeptide 1, opposite strand Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 28, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interaction of MAP17 with NHERF3/4 induces translocation of the renal Na/Pi IIa transporter to the trans-Golgi. Lanaspa MA, et al. Am J Physiol Renal Physiol, 2007 Jan. PMID 16926447
    2. Systematic analysis of a simple adaptor protein PDZK1: ligand identification, interaction and functional prediction of complex. Hu S, et al. Cell Physiol Biochem, 2009. PMID 19710538
    3. PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling. Ikeno S, et al. J Biol Chem, 2019 Mar 29. PMID 30718277, Free PMC Article
    4. Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels. Silver DL, et al. J Biol Chem, 2003 Aug 1. PMID 12754212
    5. Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension. Seidler U, et al. Exp Physiol, 2009 Feb. PMID 18931049

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings indicate that PDZK1IP1 interacts with Smad4 and thereby suppresses the TGF-beta signaling pathway.
      Title: PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling.
    2. Systematic analysis of Pdzk1ip1 is reported.
      Title: Systematic analysis of a simple adaptor protein PDZK1: ligand identification, interaction and functional prediction of complex.
    3. Knockout mice for 3 members of the sodium-hydrogen regulatory factor (NHERF) family of PDZ adaptor proteins, NHERF1 (EBP50), NHERF2 (E3KARP) and NHERF3 (PDZK1), have helped to show that NHERF1 is essential for both normal and mutant CFTR function [review]
      Title: Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension.
    4. MAP17 1) interacts with PDZK1 only, 2) associates with the NH2 terminus of NaPi-IIa within the PDZK1/NaPi-IIa/MAP17 complex, and 3) acts as an apical anchoring site for PDZK1.
      Title: Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells.
    5. membrane associated protein 17 may be an endogenous regulator of cellular PDZ domain containing 1(PDZK1) levels by regulating PDZK1 turnover
      Title: Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels.
    6. the interaction between MAP17, NHERF3/4, and NaPiIIa in the trans-Golgi network could be an important intermediate or alternate path in the internalization of NaPiIIa
      Title: Interaction of MAP17 with NHERF3/4 induces translocation of the renal Na/Pi IIa transporter to the trans-Golgi.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PDZK1-interacting protein 1
    Names
    17 kDa membrane-associated protein
    membrane-associated protein 17 (Map17)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164557.1 → NP_001158029.1  PDZK1-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001158029.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK007936, AL670035, DV058382, EH108199
      Consensus CDS
      CCDS51272.1
      UniProtKB/TrEMBL
      G3UW41
      Related
      ENSMUSP00000128118.2, ENSMUST00000171877.8
      Conserved Domains (1) summary
      pfam15807
      Location:84 → 181
      MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1

    2. NM_001164558.1 → NP_001158030.1  PDZK1-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001158030.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a segment of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AL645473, AL670035, DV057288, DV058382
      Consensus CDS
      CCDS18487.1
      UniProtKB/Swiss-Prot
      Q9CQH0
      UniProtKB/TrEMBL
      A8C1X3
      Related
      ENSMUSP00000136049.2, ENSMUST00000177647.8
      Conserved Domains (1) summary
      pfam15807
      Location:6 → 114
      MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1

    3. NM_026018.3 → NP_080294.1  PDZK1-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_080294.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK008253, AL670035, DV058382
      Consensus CDS
      CCDS18487.1
      UniProtKB/Swiss-Prot
      Q9CQH0
      UniProtKB/TrEMBL
      A8C1X3
      Related
      ENSMUSP00000102158.3, ENSMUST00000106548.9
      Conserved Domains (1) summary
      pfam15807
      Location:6 → 114
      MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      114945905..114951091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253719.2 → XP_030109579.1  PDZK1-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9CQH0
      UniProtKB/TrEMBL
      A8C1X3
      Conserved Domains (1) summary
      pfam15807
      Location:6 → 114
      MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQH0.1 GenPept UniProtKB/Swiss-Prot:Q9CQH0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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