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    Tmc7 transmembrane channel-like gene family 7 [ Mus musculus (house mouse) ]

    Gene ID: 209760, updated on 23-Dec-2024

    Summary

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    Official Symbol
    Tmc7provided by MGI
    Official Full Name
    transmembrane channel-like gene family 7provided by MGI
    Primary source
    MGI:MGI:2443317
    See related
    Ensembl:ENSMUSG00000042246 AllianceGenome:MGI:2443317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C230064B05; 1700030H01Rik; C630024K23Rik
    Summary
    Enables ion channel inhibitor activity. Involved in sensory perception of mechanical stimulus. Predicted to be located in plasma membrane. Orthologous to human TMC7 (transmembrane channel like 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 39.3), cerebellum adult (RPKM 4.2) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmc7 in Genome Data Viewer
    Location:
    7 F1; 7 63.44 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (118135064..118184052, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118535841..118584829, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51516 Neighboring gene demethyl-Q 7 Neighboring gene STARR-positive B cell enhancer ABC_E1093 Neighboring gene RIKEN cDNA B230311B06 gene Neighboring gene transmembrane channel-like gene family 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice. Wang J, et al. Elife, 2024 Sep 13. PMID 39269275, Free PMC Article
    2. TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction. Zhang X, et al. Cell Rep, 2024 Apr 23. PMID 38568807
    3. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. Kurima K, et al. Genomics, 2003 Sep. PMID 12906855
    4. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. Keresztes G, et al. BMC Genomics, 2003 Jun 17. PMID 12812529, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice.
      Title: TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ion channel inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sensory perception of mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane channel-like protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172476.5 → NP_766064.2  transmembrane channel-like protein 7

      See identical proteins and their annotated locations for NP_766064.2

      Status: VALIDATED

      Source sequence(s)
      AC122912, AC124444
      Consensus CDS
      CCDS21772.1
      UniProtKB/Swiss-Prot
      Q7TN59, Q7TQ66, Q8C428, Q8C4C3
      Related
      ENSMUSP00000046927.5, ENSMUST00000044195.6
      Conserved Domains (1) summary
      pfam07810
      Location:489 → 590
      TMC; TMC domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      118135064..118184052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507550.5 → XP_006507613.1  transmembrane channel-like protein 7 isoform X1

      Conserved Domains (1) summary
      pfam07810
      Location:376 → 487
      TMC; TMC domain

    2. XM_036152862.1 → XP_036008755.1  transmembrane channel-like protein 7 isoform X1

      Conserved Domains (1) summary
      pfam07810
      Location:376 → 487
      TMC; TMC domain

    RNA

    1. XR_003946428.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C428.1 GenPept UniProtKB/Swiss-Prot:Q8C428

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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