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    Arl8a ADP-ribosylation factor-like 8A [ Mus musculus (house mouse) ]

    Gene ID: 68724, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arl8aprovided by MGI
    Official Full Name
    ADP-ribosylation factor-like 8Aprovided by MGI
    Primary source
    MGI:MGI:1915974
    See related
    Ensembl:ENSMUSG00000026426 AllianceGenome:MGI:1915974
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gie2; Arl10b; 1110033P22Rik
    Summary
    Predicted to enable GTP binding activity. Involved in anterograde axonal transport. Predicted to be located in cytoplasm; midbody; and spindle midzone. Predicted to be active in lysosomal membrane. Is expressed in cortical plate; ganglia; sensory organ; and submandibular gland primordium. Orthologous to human ARL8A (ARF like GTPase 8A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 133.7), whole brain E14.5 (RPKM 99.2) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arl8a in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135074572..135084007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135146834..135156268)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6 Neighboring gene STARR-seq mESC enhancer starr_02346 Neighboring gene STARR-seq mESC enhancer starr_02347 Neighboring gene protein tyrosine phosphatase receptor type V Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:137029652-137029867 Neighboring gene STARR-positive B cell enhancer ABC_E9480 Neighboring gene protein tyrosine phosphatase, non-receptor type 7 Neighboring gene G protein-coupled receptor 37-like 1 Neighboring gene STARR-seq mESC enhancer starr_02353 Neighboring gene STARR-seq mESC enhancer starr_02355 Neighboring gene predicted gene, 41955

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. Okai T, et al. J Cell Sci, 2004 Sep 15. PMID 15331635
    2. Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles. Vukoja A, et al. Neuron, 2018 Sep 19. PMID 30174114
    3. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    4. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
    5. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde axonal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anterograde axonal transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle midzone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 8A
    Names
    ADP-ribosylation factor-like 10B
    ADP-ribosylation factor-like protein 10B
    novel small G protein indispensable for equal chromosome segregation 2
    small G protein indispensable for equal chromosome segregation 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026823.2 → NP_081099.1  ADP-ribosylation factor-like protein 8A

      See identical proteins and their annotated locations for NP_081099.1

      Status: PROVISIONAL

      Source sequence(s)
      AC133097
      Consensus CDS
      CCDS15316.1
      UniProtKB/Swiss-Prot
      Q8VEH3, Q99KS1, Q9CTB0
      UniProtKB/TrEMBL
      Q9DAB3
      Related
      ENSMUSP00000027684.5, ENSMUST00000027684.11
      Conserved Domains (1) summary
      cd04159
      Location:22 → 180
      Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      135074572..135084007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153366.1 → XP_036009259.1  ADP-ribosylation factor-like protein 8A isoform X1

      UniProtKB/TrEMBL
      F6QKK2
      Related
      ENSMUSP00000121545.2, ENSMUST00000125774.2
      Conserved Domains (1) summary
      cd04159
      Location:1 → 132
      Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEH3.1 GenPept UniProtKB/Swiss-Prot:Q8VEH3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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