Scgb3a2 secretoglobin, family 3A, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scgb3a2provided by MGI
Official Full Name: secretoglobin, family 3A, member 2provided by MGI
Primary source: MGI:MGI:2153470
See related: Ensembl:ENSMUSG00000038791 AllianceGenome:MGI:2153470
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pnsp1; UGRP1; LuLeu1; Utgrp1
Summary: Located in extracellular region. Is expressed in several structures, including mammary gland; respiratory system; and thyroid gland. Human ortholog(s) of this gene implicated in allergic rhinitis and asthma. Orthologous to human SCGB3A2 (secretoglobin family 3A member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward lung adult (RPKM 559.3) See more
Orthologs: human all
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Genomic context

Location:: 18 B3; 18 23.49 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (43897346..43900464)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (43764301..43767399)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Uterus globulin associated protein 1 (UGRP1) binds podoplanin (PDPN) to promote a novel inflammation pathway during Streptococcus pneumoniae infection.
Title: Uterus globulin associated protein 1 (UGRP1) binds podoplanin (PDPN) to promote a novel inflammation pathway during Streptococcus pneumoniae infection.
Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia
Title: Spatiotemporal Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia.
It has been shown that Scgb3a2 chaperones LPS to the cytosol through the cell surface receptor syndecan-1; this leads to pyroptotic lung cancer cell death driven by caspase-11.
Title: A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death.
These results demonstrate that SCGB3A2 has an anti-inflammatory activity in the HDM-induced allergic airway inflammation model, in which SCGB3A2 may modulate the CCR4-CCL17 pathway.
Title: Secretoglobin Superfamily Protein SCGB3A2 Alleviates House Dust Mite-Induced Allergic Airway Inflammation in Mice.
The pulmonary fibrosis in the Scgb3a2-null mice was more severe than the wild-type controls, thus establishing that SCGB3A2 has anti-fibrotic activity in vivo.
Title: Secretoglobin 3A2 Exhibits Anti-Fibrotic Activity in Bleomycin-Induced Pulmonary Fibrosis Model Mice.
SCGB3A2 is an anti-fibrotic agent, and suggest a possible therapeutic use of recombinant SCGB3A2 in the treatment of pulmonary fibrosis.
Title: Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice.
The results indicate that the loss of SCGB3A2 function was influenced by a modifier gene(s) in mixed genetic background and suggest that SCGB3A2 has anti-inflammatory property.
Title: Secretoglobin superfamily protein SCGB3A2 deficiency potentiates ovalbumin-induced allergic pulmonary inflammation.
SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe.
Title: Regulation of LH/FSH expression by secretoglobin 3A2 in the mouse pituitary gland.
Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation
Title: Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation.
Results demonstrate that SCGB3A2 is a useful marker for diagnosis of pulmonary tumors both in mice and humans.
Title: Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: secretoglobin family 3A member 2

Names: pneumo secretory protein 1; uteroglobin related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289643.1 → NP_001276572.1 secretoglobin family 3A member 2 isoform 1

See identical proteins and their annotated locations for NP_001276572.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF274960, BY120182

Consensus CDS

CCDS79641.1

UniProtKB/Swiss-Prot

Q920H1

Related

ENSMUSP00000140375.2, ENSMUST00000189750.2

Conserved Domains (1) summary

pfam01099
Location:58 → 92

Uteroglobin; Uteroglobin family
NM_001289644.1 → NP_001276573.1 secretoglobin family 3A member 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_001276573.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AF274960, AK136373, BY120182

Consensus CDS

CCDS79640.1

UniProtKB/Swiss-Prot

Q5D060, Q920H1, Q920H2, Q920H3

Related

ENSMUSP00000140476.2, ENSMUST00000187157.7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

43897346..43900464

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160942.1 → XP_036016835.1 secretoglobin family 3A member 2 isoform X1

Related

ENSMUSP00000038872.7, ENSMUST00000043803.13

Conserved Domains (1) summary

pfam01099
Location:1 → 92

Uteroglobin; Uteroglobin family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_054038.1: Suppressed sequence

Description

NM_054038.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.