Rnf43 ring finger protein 43 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf43provided by MGI
Official Full Name: ring finger protein 43provided by MGI
Primary source: MGI:MGI:2442609
See related: Ensembl:ENSMUSG00000034177 AllianceGenome:MGI:2442609
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4732452J19Rik
Summary: Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in negative regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; forelimb epidermis; genitourinary system; lung; and submandibular gland primordium. Human ortholog(s) of this gene implicated in endometrial cancer; gastrointestinal system cancer (multiple); irritable bowel syndrome; lung adenocarcinoma; and villous adenoma. Orthologous to human RNF43 (ring finger protein 43). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in duodenum adult (RPKM 7.3), colon adult (RPKM 5.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 52.17 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (87553913..87626365)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (87663087..87735539)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Selective epigenetic alterations in RNF43 in pancreatic exocrine cells from high-fat-diet-induced obese mice; implications for pancreatic cancer.
Title: Selective epigenetic alterations in RNF43 in pancreatic exocrine cells from high-fat-diet-induced obese mice; implications for pancreatic cancer.
RNF43 induces the turnover of protease-activated receptor 2 in colon cancer.
Title: RNF43 induces the turnover of protease-activated receptor 2 in colon cancer.
Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma.
Title: Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma.
RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
Title: RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response.
Title: Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response.
Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation.
Title: Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation.
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.
Title: ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.
A DNA repair player, ring finger protein 43, relieves etoposide-induced topoisomerase II poisoning.
Title: A DNA repair player, ring finger protein 43, relieves etoposide-induced topoisomerase II poisoning.
Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma.
Title: Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma.
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
Title: A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491804

D10Chm6 (e-PCR)
- UniSTS:518047

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IEA Inferred from Electronic Annotation more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt receptor catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in Wnt receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in Wnt receptor catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF43

Names: RING-type E3 ubiquitin transferase RNF43

NP_001350366.1

EC 2.3.2.27

NP_766036.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363437.1 → NP_001350366.1 E3 ubiquitin-protein ligase RNF43 isoform 2

Status: VALIDATED

Source sequence(s)

AK028750, AL604022

Consensus CDS

CCDS88216.1

UniProtKB/TrEMBL

A3KMI3, E9PWJ5

Related

ENSMUSP00000044241.5, ENSMUST00000040089.5

Conserved Domains (2) summary

cd16798
Location:143 → 189

RING-H2_RNF43; RING finger, H2 subclass, found in RING finger protein 43 (RNF43) and similar proteins

cl28271
Location:472 → 629

dnaA; chromosomal replication initiation protein; Provisional
NM_172448.4 → NP_766036.2 E3 ubiquitin-protein ligase RNF43 isoform 1 precursor

See identical proteins and their annotated locations for NP_766036.2

Status: VALIDATED

Source sequence(s)

AK032782, BC131957, CF747567

Consensus CDS

CCDS25215.2

UniProtKB/Swiss-Prot

B2KGH3, Q5NCP0, Q6DI76, Q8BME0, Q8C191, Q8K0X4

UniProtKB/TrEMBL

E9PWJ5

Related

ENSMUSP00000130685.2, ENSMUST00000165679.8

Conserved Domains (1) summary

pfam13639
Location:270 → 312

zf-RING_2; Ring finger domain