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    Gas2l3 growth arrest-specific 2 like 3 [ Mus musculus (house mouse) ]

    Gene ID: 237436, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gas2l3provided by MGI
    Official Full Name
    growth arrest-specific 2 like 3provided by MGI
    Primary source
    MGI:MGI:1918780
    See related
    Ensembl:ENSMUSG00000074802 AllianceGenome:MGI:1918780
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm240; 8430435B07Rik
    Summary
    Predicted to enable actin filament binding activity and microtubule binding activity. Acts upstream of or within response to bacterium. Predicted to be located in actin cytoskeleton and microtubule cytoskeleton. Is expressed in heart. Orthologous to human GAS2L3 (growth arrest specific 2 like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 3.1), CNS E11.5 (RPKM 1.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gas2l3 in Genome Data Viewer
    Location:
    10 C2; 10 44.98 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (89244684..89279935, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (89408822..89443980, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 (iodide transporter), member 8 Neighboring gene STARR-seq mESC enhancer starr_27514 Neighboring gene STARR-seq mESC enhancer starr_27515 Neighboring gene anoctamin 4 Neighboring gene predicted gene, 30769 Neighboring gene STARR-seq mESC enhancer starr_27517 Neighboring gene STARR-positive B cell enhancer ABC_E6898 Neighboring gene STARR-seq mESC enhancer starr_27520 Neighboring gene STARR-positive B cell enhancer ABC_E1404 Neighboring gene STARR-seq mESC enhancer starr_27521 Neighboring gene nuclear receptor subfamily 1, group H, member 4 Neighboring gene solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes. Gründl M, et al. PLoS Genet, 2020 May. PMID 32469866, Free PMC Article
    2. Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development. Stopp S, et al. Proc Natl Acad Sci U S A, 2017 Jul 25. PMID 28698371, Free PMC Article
    3. Single-cell transcriptomic analysis of mouse neocortical development. Loo L, et al. Nat Commun, 2019 Jan 11. PMID 30635555, Free PMC Article
    4. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
    5. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    GAS2-like protein 3
    Names
    growth arrest-specific protein 2-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033331.2 → NP_001028503.2  GAS2-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001028503.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC152417, AK136054, BY205636, CF165165
      Consensus CDS
      CCDS24115.1
      UniProtKB/Swiss-Prot
      Q3TCF5, Q3UWW6
      UniProtKB/TrEMBL
      A0A0R4J1A6
      Related
      ENSMUSP00000100935.2, ENSMUST00000105298.3
      Conserved Domains (3) summary
      cd00014
      Location:51 → 169
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam05109
      Location:335 → 682
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02187
      Location:215 → 283
      GAS2; Growth-Arrest-Specific Protein 2 Domain

    2. NM_001079876.1 → NP_001073345.1  GAS2-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001073345.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, resulting in a 3-nt longer 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC152417, AK136054, BY205636, BY208646, CF165165
      Consensus CDS
      CCDS24115.1
      UniProtKB/Swiss-Prot
      Q3TCF5, Q3UWW6
      UniProtKB/TrEMBL
      A0A0R4J1A6
      Related
      ENSMUSP00000096973.3, ENSMUST00000099374.9
      Conserved Domains (3) summary
      cd00014
      Location:51 → 169
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam05109
      Location:335 → 682
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02187
      Location:215 → 283
      GAS2; Growth-Arrest-Specific Protein 2 Domain

    3. NM_001284344.1 → NP_001271273.1  GAS2-like protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001271273.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a split 3' exon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC152417, AK136054, AK164505, BY205636
      Consensus CDS
      CCDS88068.1
      UniProtKB/TrEMBL
      Q3TPC3
      Related
      ENSMUSP00000151240.2, ENSMUST00000220128.2
      Conserved Domains (2) summary
      cd00014
      Location:51 → 169
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam02187
      Location:216 → 283
      GAS2; Growth-Arrest-Specific Protein 2 Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      89244684..89279935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243445.3 → XP_011241747.1  GAS2-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011241747.1

      UniProtKB/Swiss-Prot
      Q3TCF5, Q3UWW6
      UniProtKB/TrEMBL
      A0A0R4J1A6
      Conserved Domains (3) summary
      cd00014
      Location:51 → 169
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam05109
      Location:335 → 682
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02187
      Location:215 → 283
      GAS2; Growth-Arrest-Specific Protein 2 Domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UWW6.1 GenPept UniProtKB/Swiss-Prot:Q3UWW6

    Gene LinkOut

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