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    Polrmt polymerase (RNA) mitochondrial (DNA directed) [ Mus musculus (house mouse) ]

    Gene ID: 216151, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polrmtprovided by MGI
    Official Full Name
    polymerase (RNA) mitochondrial (DNA directed)provided by MGI
    Primary source
    MGI:MGI:1915843
    See related
    Ensembl:ENSMUSG00000020329 AllianceGenome:MGI:1915843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mtRPOL; 4932416K13; 1110018N15Rik
    Summary
    Enables sequence-specific DNA binding activity. Predicted to be involved in transcription initiation at mitochondrial promoter. Located in mitochondrion. Part of protein-containing complex. Is expressed in early conceptus; limb mesenchyme; and secondary oocyte. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 55. Orthologous to human POLRMT (RNA polymerase mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 28.6), ovary adult (RPKM 26.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Polrmt in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79571951..79582436, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79736125..79746604, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10624 Neighboring gene basigin Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 2 Neighboring gene STARR-positive B cell enhancer ABC_E3897 Neighboring gene fibroblast growth factor 22 Neighboring gene ring finger protein 126 Neighboring gene STARR-positive B cell enhancer ABC_E899

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. POLRMT does not transcribe nuclear genes. Kühl I, et al. Nature, 2014 Oct 9. PMID 25297440
    2. POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA. Kühl I, et al. Sci Adv, 2016 Aug. PMID 27532055, Free PMC Article
    3. TEFM regulates both transcription elongation and RNA processing in mitochondria. Jiang S, et al. EMBO Rep, 2019 Jun. PMID 31036713, Free PMC Article
    4. Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro. Lodeiro MF, et al. Proc Natl Acad Sci U S A, 2012 Apr 24. PMID 22493245, Free PMC Article
    5. SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression. Yan W, et al. EMBO J, 2024 Jun. PMID 38649537, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.
      Title: SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.
    2. we present in vivo evidence that POLRMT has a key regulatory role in the replication of mammalian mtDNA and is part of a transcriptional mechanism that provides a switch between primer formation for mtDNA replication and mitochondrial gene expression.
      Title: POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA.
    3. POLRMT recognizes promoter elements in a sequence specific manner; TFAM induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition
      Title: The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118526

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA primase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA primase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase I activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase III activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase IV activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase V activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitochondrial promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitochondrial single subunit type RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables plastid single subunit type RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication, synthesis of primer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plastid transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase V IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at mitochondrial promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at mitochondrial promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial DNA-directed RNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase, mitochondrial
    Names
    mitochondrial DNA-directed RNA polymerase
    NP_001394721.1
    NP_001394722.1
    NP_001394723.1
    NP_001394724.1
    NP_001394725.1
    NP_001394726.1
    NP_001394727.1
    NP_001394728.1
    NP_766139.2
    XP_030100878.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001407792.1 → NP_001394721.1  DNA-directed RNA polymerase, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      Q3V3C0

    2. NM_001407793.1 → NP_001394722.1  DNA-directed RNA polymerase, mitochondrial isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      Q3V3C0

    3. NM_001407794.1 → NP_001394723.1  DNA-directed RNA polymerase, mitochondrial isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      Q3V3C0

    4. NM_001407795.1 → NP_001394724.1  DNA-directed RNA polymerase, mitochondrial isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      E9PWD9, Q3V3C0
      Related
      ENSMUSP00000124936.2, ENSMUST00000159016.8

    5. NM_001407796.1 → NP_001394725.1  DNA-directed RNA polymerase, mitochondrial isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      Q3V3C0

    6. NM_001407797.1 → NP_001394726.1  DNA-directed RNA polymerase, mitochondrial isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      Q3V3C0

    7. NM_001407798.1 → NP_001394727.1  DNA-directed RNA polymerase, mitochondrial isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      Q3V3C0

    8. NM_001407799.1 → NP_001394728.1  DNA-directed RNA polymerase, mitochondrial isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      Q3V3C0

    9. NM_172551.4 → NP_766139.2  DNA-directed RNA polymerase, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_766139.2

      Status: VALIDATED

      Source sequence(s)
      AC151828
      Consensus CDS
      CCDS23987.1
      UniProtKB/Swiss-Prot
      Q8BJE0, Q8BKF1
      UniProtKB/TrEMBL
      Q3U3J3, Q3V3C0
      Related
      ENSMUSP00000020580.7, ENSMUST00000020580.13
      Conserved Domains (4) summary
      PHA00452
      Location:437 → 1207
      PHA00452; T3/T7-like RNA polymerase
      sd00004
      Location:233 → 262
      PPR; PPR repeat [structural motif]
      pfam00940
      Location:802 → 1206
      RNA_pol; DNA-dependent RNA polymerase
      pfam14700
      Location:374 → 674
      RPOL_N; DNA-directed RNA polymerase N-terminal

    RNA

    1. NR_176423.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC151828
      Related
      ENSMUST00000162694.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79571951..79582436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245018.2 → XP_030100878.1  DNA-directed RNA polymerase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q3V3C0
      Conserved Domains (3) summary
      sd00004
      Location:233 → 262
      PPR; PPR repeat [structural motif]
      pfam00940
      Location:802 → 1236
      RNA_pol; DNA-dependent RNA polymerase
      pfam14700
      Location:375 → 675
      RPOL_N; DNA-directed RNA polymerase N-terminal

    RNA

    1. XR_003948668.2 RNA Sequence

      Related
      ENSMUST00000159082.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BKF1.1 GenPept UniProtKB/Swiss-Prot:Q8BKF1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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