Ctnnal1 catenin alpha like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctnnal1provided by MGI
Official Full Name: catenin alpha like 1provided by MGI
Primary source: MGI:MGI:1859649
See related: Ensembl:ENSMUSG00000038816 AllianceGenome:MGI:1859649
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ACRP; Catnal1
Summary: Predicted to enable actin filament binding activity and cadherin binding activity. Predicted to be involved in Rho protein signal transduction. Predicted to be located in cytosol. Is expressed in several structures, including dermomyotome; embryo ectoderm; gut; peripheral nervous system; and sensory organ. Orthologous to human CTNNAL1 (catenin alpha like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 18.0), CNS E11.5 (RPKM 7.9) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 31.66 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (56810935..56865370, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (56810935..56865375, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTNNAL1 promotes the structural integrity of bronchial epithelial cells through the RhoA/ROCK1 pathway.
Title: CTNNAL1 promotes the structural integrity of bronchial epithelial cells through the RhoA/ROCK1 pathway.
CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma mouse model through ROCK1-CAL signaling pathway.
Title: CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma mouse model through ROCK1-CAL signaling pathway.
CTNNAL1 participates in the regulation of mucus overproduction in HDM-induced asthma mouse model through the YAP-ROCK2 pathway.
Title: CTNNAL1 participates in the regulation of mucus overproduction in HDM-induced asthma mouse model through the YAP-ROCK2 pathway.
Force-dependent conformational switch of alpha-catenin controls vinculin binding.
Title: Force-dependent conformational switch of α-catenin controls vinculin binding.
Alpha-catenin has a novel role in fine-tuning of tissues' viscosity and surface tension through contractility.
Title: Fine tuning of tissues' viscosity and surface tension through contractility suggests a new role for α-catenin.
the interaction between alpha-catulin and alpha-dystrobrevin is evolutionarily conserved in C. elegans and mouse muscles and strongly suggests that this interaction contributes to the integrity of the dystrophin complex
Title: Interaction of α-catulin with dystrobrevin contributes to integrity of dystrophin complex in muscle.
This study identifies the E-cadherin/catenin complex as a discriminative, partly polyamine-regulated feature of IL-4/IL-13-exposed alternatively activated macrophages
Title: Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes.
We observed the temporal and spatial distribution of CTNNAL1 expression in mouse lung tissue with the OVA-sensitized asthma model and found that the level of CTNNAL1 mRNA showed a prominent negative correlation with pulmonary resistance.
Title: Wound repair and proliferation of bronchial epithelial cells regulated by CTNNAL1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (3) 1 citation

General gene information

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Markers

RH127248 (e-PCR)
- UniSTS:207619

AW545119 (e-PCR)
- UniSTS:179006

AI616177 (e-PCR)
- UniSTS:179007

AI957324 (e-PCR)
- UniSTS:164237

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-catulin

Names: alpha-catenin related protein; catenin (cadherin associated protein), alpha-like 1; catenin alpha-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.