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    Purg purine-rich element binding protein G [ Mus musculus (house mouse) ]

    Gene ID: 75029, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Purgprovided by MGI
    Official Full Name
    purine-rich element binding protein Gprovided by MGI
    Primary source
    MGI:MGI:1922279
    See related
    Ensembl:ENSMUSG00000049184 AllianceGenome:MGI:1922279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930486B15Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and purine-rich negative regulatory element binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is active in synapse. Is expressed in glossopharyngeal ganglion and midbrain mantle layer. Orthologous to human PURG (purine rich element binding protein G). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E18 (RPKM 7.5), CNS E14 (RPKM 5.3) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Purg in Genome Data Viewer
    Location:
    8 A3; 8 20.3 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (33875650..33907500)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33385619..33417472)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21100 Neighboring gene GTP-binding protein 10 (putative) pseudogene Neighboring gene STARR-seq mESC enhancer starr_21101 Neighboring gene Werner syndrome RecQ like helicase Neighboring gene STARR-seq mESC enhancer starr_21102 Neighboring gene STARR-seq mESC enhancer starr_21104 Neighboring gene STARR-seq mESC enhancer starr_21105 Neighboring gene translocase of outer mitochondrial membrane 40 homolog pseudogene Neighboring gene high mobility group box 1, related sequence 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation. Liu H, et al. Nucleic Acids Res, 2002 Jun 1. PMID 12034829, Free PMC Article
    2. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
    3. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087
    4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine-rich negative regulatory element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-rich negative regulatory element binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    purine-rich element-binding protein gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098233.1 → NP_001091703.1  purine-rich element-binding protein gamma isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate 3' exon, compared to unspliced variant 1. This produces a unique 3' UTR, and the encoded isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC115809, AF479673, AI931378, BE648043, CD772246
      Consensus CDS
      CCDS52538.1
      UniProtKB/Swiss-Prot
      Q8R4E6
      Related
      ENSMUSP00000077205.4, ENSMUST00000078058.5
      Conserved Domains (1) summary
      pfam04845
      Location:60 → 293
      PurA; PurA ssDNA and RNA-binding protein

    2. NM_001382855.1 → NP_001369784.1  purine-rich element-binding protein gamma isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same protein.
      Source sequence(s)
      AC115809
      UniProtKB/Swiss-Prot
      Q14B11, Q8R4E6, Q8R4E7
      Conserved Domains (1) summary
      pfam04845
      Location:60 → 324
      PurA; PurA ssDNA and RNA-binding protein

    3. NM_152821.2 → NP_690034.1  purine-rich element-binding protein gamma isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is unspliced and encodes the longer isoform (a).
      Source sequence(s)
      AC115809, AF479673, AK015630
      Consensus CDS
      CCDS22230.1
      UniProtKB/Swiss-Prot
      Q14B11, Q8R4E6, Q8R4E7
      Related
      ENSMUSP00000065002.5, ENSMUST00000070340.6
      Conserved Domains (1) summary
      pfam04845
      Location:60 → 324
      PurA; PurA ssDNA and RNA-binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      33875650..33907500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154347.1 → XP_036010240.1  purine-rich element-binding protein gamma isoform X3

      Conserved Domains (1) summary
      pfam04845
      Location:60 → 295
      PurA; PurA ssDNA and RNA-binding protein

    2. XM_036154346.1 → XP_036010239.1  purine-rich element-binding protein gamma isoform X1

      Conserved Domains (1) summary
      pfam04845
      Location:60 → 295
      PurA; PurA ssDNA and RNA-binding protein

    3. XM_011242166.4 → XP_011240468.1  purine-rich element-binding protein gamma isoform X4

      Conserved Domains (1) summary
      pfam04845
      Location:60 → 292
      PurA; PurA ssDNA and RNA-binding protein

    4. XM_006509205.3 → XP_006509268.1  purine-rich element-binding protein gamma isoform X2

      Conserved Domains (1) summary
      pfam04845
      Location:60 → 292
      PurA; PurA ssDNA and RNA-binding protein

    5. XM_017312994.3 → XP_017168483.1  purine-rich element-binding protein gamma isoform X5

      Conserved Domains (1) summary
      pfam04845
      Location:60 → 297
      PurA; PurA ssDNA and RNA-binding protein

    6. XM_006509209.5 → XP_006509272.1  purine-rich element-binding protein gamma isoform X6

      UniProtKB/Swiss-Prot
      Q8R4E6
      Conserved Domains (1) summary
      pfam04845
      Location:60 → 293
      PurA; PurA ssDNA and RNA-binding protein

    RNA

    1. XR_004934894.1 RNA Sequence

    2. XR_004934895.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4E6.1 GenPept UniProtKB/Swiss-Prot:Q8R4E6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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