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    ACS4 1-aminocyclopropane-1-carboxylate synthase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816812, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACS4
    Official Full Name
    1-aminocyclopropane-1-carboxylate synthase 4
    Primary source
    TAIR:AT2G22810
    Locus tag
    AT2G22810
    See related
    Araport:AT2G22810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE; 1-aminocyclopropane-1-carboxylate synthase 4; 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID SYNTHASE POLYPEPTIDE; 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID SYNTHASE POLYPEPTIDE; ACC4; ATACS4; T30L20.7
    Summary
    key regulatory enzyme in the biosynthesis of the plant hormone ethylene. ACS4 is specifically induced by indoleacetic acid (IAA).
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    Genomic context

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    See ACS4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (9717602..9719594, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Defensin-like (DEFL) family protein Neighboring gene Defensin-like (DEFL) family protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene squalene epoxidase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ACS4, a primary indoleacetic acid-responsive gene encoding 1-aminocyclopropane-1-carboxylate synthase in Arabidopsis thaliana. Structural characterization, expression in Escherichia coli, and expression characteristics in response to auxin [corrected]. Abel S, et al. J Biol Chem, 1995 Aug 11. PMID 7642574
    2. Abscisic Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis. Dong Z, et al. Mol Plant, 2016 Jan 4. PMID 26410794
    3. Arabidopsis RING E3 ligase XBAT32 regulates lateral root production through its role in ethylene biosynthesis. Prasad ME, et al. Plant Physiol, 2010 Aug. PMID 20511490, Free PMC Article
    4. The GUS reporter-aided analysis of the promoter activities of Arabidopsis ACC synthase genes AtACS4, AtACS5, and AtACS7 induced by hormones and stresses. Wang NN, et al. J Exp Bot, 2005 Mar. PMID 15699063
    5. The BTB ubiquitin ligases ETO1, EOL1 and EOL2 act collectively to regulate ethylene biosynthesis in Arabidopsis by controlling type-2 ACC synthase levels. Christians MJ, et al. Plant J, 2009 Jan. PMID 18808454, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results demonstrate that ABA negatively regulates ethylene production through ABI4-mediated transcriptional repression of the ethylene biosynthesis genes ACS4 and ACS8
      Title: Abscisic Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis.
    2. Expression in response to plant growth regulators and abiotic stress in roots and aerial parts as demonstrated by expression of the GUS reporter in A. thaliana.
      Title: The GUS reporter-aided analysis of the promoter activities of Arabidopsis ACC synthase genes AtACS4, AtACS5, and AtACS7 induced by hormones and stresses.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-aminocyclopropane-1-carboxylate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within 1-aminocyclopropane-1-carboxylate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ethylene biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ethylene biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    1-aminocyclopropane-1-carboxylate synthase 4
    NP_179866.1
    • 1-aminocyclopropane-1-carboxylate synthase 4 (ACS4); CONTAINS InterPro DOMAIN/s: 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase, class I/classII (InterPro:IPR004839), Aminotransferases, class-I, pyridoxal-phosphate-binding site (InterPro:IPR004838), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: 1-amino-cyclopropane-1-carboxylate synthase 8 (TAIR:AT4G37770.1); Has 28174 Blast hits to 28171 proteins in 2873 species: Archae - 784; Bacteria - 19102; Metazoa - 651; Fungi - 724; Plants - 1302; Viruses - 0; Other Eukaryotes - 5611 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9717602..9719594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127846.2 → NP_179866.1  1-aminocyclopropane-1-carboxylate synthase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179866.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q43309, Q9S9C4
      UniProtKB/TrEMBL
      A0A178VTT6, A0A5S9X0B2
      Conserved Domains (2) summary
      PLN02450
      Location:1 → 473
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase
      cl18945
      Location:4 → 147
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q43309.1

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