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    HIT1 Membrane trafficking VPS53 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841472, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HIT1
    Official Full Name
    Membrane trafficking VPS53 family protein
    Primary source
    TAIR:AT1G50500
    Locus tag
    AT1G50500
    See related
    Araport:AT1G50500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA VPS53 HOMOLOG; ATVPS53; HEAT-INTOLERANT 1; VPS53
    Summary
    encodes a member of VPS53 family protein involved in the retrograde trafficking of vesicles to the late Golgi. Mutants in this gene are more sensitive to heat and osmotic stress.
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    Genomic context

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    See HIT1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    24
    Sequence:
    Chromosome: 1; NC_003070.9 (18707924..18716118, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene 10-formyltetrahydrofolate synthetase Neighboring gene ubiquitin-conjugating enzyme 20 Neighboring gene indigoidine synthase A family protein Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 27 Neighboring gene uncharacterized protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis hit1-1 mutant has a plasma membrane profile distinct from that of wild-type plants at optimal growing temperature. Wang LC, et al. Plant Signal Behav, 2011 Aug. PMID 21758000, Free PMC Article
    2. Mutation in a homolog of yeast Vps53p accounts for the heat and osmotic hypersensitive phenotypes in Arabidopsis hit1-1 mutant. Lee CF, et al. Planta, 2006 Jul. PMID 16408208
    3. Involvement of the Arabidopsis HIT1/AtVPS53 tethering protein homologue in the acclimation of the plasma membrane to heat stress. Wang LC, et al. J Exp Bot, 2011 Jun. PMID 21398432
    4. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The hit1-1 mutation essentially alters vesicle trafficking and results in changes in the plasma membrane components under non-stress conditions.
      Title: The Arabidopsis hit1-1 mutant has a plasma membrane profile distinct from that of wild-type plants at optimal growing temperature.
    2. HIT1 may be involved in vesicle trafficking in plant stress responses.[HIT1]
      Title: Mutation in a homolog of yeast Vps53p accounts for the heat and osmotic hypersensitive phenotypes in Arabidopsis hit1-1 mutant.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001198259.1
    NM_001333440.1
    NM_001333441.1
    NM_001333442.1
    NM_103933.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GARP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GARP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Membrane trafficking VPS53 family protein
    NP_001185188.1
    • HEAT-INTOLERANT 1 (HIT1); CONTAINS InterPro DOMAIN/s: Vps53-like, N-terminal (InterPro:IPR007234); BEST Arabidopsis thaliana protein match is: Membrane trafficking VPS53 family protein (TAIR:AT1G50970.1).
    NP_564573.3
    • HEAT-INTOLERANT 1 (HIT1); CONTAINS InterPro DOMAIN/s: Vps53-like, N-terminal (InterPro:IPR007234); BEST Arabidopsis thaliana protein match is: Membrane trafficking VPS53 family protein (TAIR:AT1G50970.1); Has 898 Blast hits to 860 proteins in 251 species: Archae - 12; Bacteria - 82; Metazoa - 379; Fungi - 169; Plants - 68; Viruses - 0; Other Eukaryotes - 188 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18707924..18716118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103933.6 → NP_564573.3  Membrane trafficking VPS53 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564573.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I6I4, Q0WQF4, Q9C6Q3, Q9LPS3
      UniProtKB/TrEMBL
      A0A178W5E4, A0A5S9WKR6, A0A654ET08
      Conserved Domains (2) summary
      pfam04100
      Location:1 → 424
      Vps53_N; Vps53-like, N-terminal
      pfam16854
      Location:650 → 729
      VPS53_C; Vacuolar protein sorting-associated protein 53 C-terminus

    2. NM_001333441.1 → NP_001322422.1  Membrane trafficking VPS53 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5E4, A0A1P8ATX5

    3. NM_001333440.1 → NP_001322424.1  Membrane trafficking VPS53 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I6I4, Q0WQF4, Q9C6Q3, Q9LPS3
      UniProtKB/TrEMBL
      A0A178W5E4, A0A5S9WKR6, A0A654ET08
      Conserved Domains (2) summary
      pfam04100
      Location:1 → 424
      Vps53_N; Vps53-like, N-terminal
      pfam16854
      Location:650 → 729
      VPS53_C; Vacuolar protein sorting-associated protein 53 C-terminus

    4. NM_001333442.1 → NP_001322423.1  Membrane trafficking VPS53 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5E4, A0A1P8ATZ0

    5. NM_001198259.1 → NP_001185188.1  Membrane trafficking VPS53 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5E4
      Conserved Domains (2) summary
      pfam04100
      Location:1 → 443
      Vps53_N; Vps53-like, N-terminal
      pfam16854
      Location:669 → 748
      VPS53_C; Vacuolar protein sorting-associated protein 53 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WQF4.1

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