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    ZNF260 zinc finger protein 260 [ Homo sapiens (human) ]

    Gene ID: 339324, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF260provided by HGNC
    Official Full Name
    zinc finger protein 260provided by HGNC
    Primary source
    HGNC:HGNC:13499
    See related
    Ensembl:ENSG00000254004 MIM:613749; AllianceGenome:HGNC:13499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PEX1; OZRF1; ZFP260
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 5.3), endometrium (RPKM 4.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF260 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36510687..36528271, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39185915..39203539, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37001589..37019173, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36980447-36981332 Neighboring gene ZNF566 antisense RNA 1 Neighboring gene CTBP2 pseudogene 7 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:37018470-37019180 and GRCh37_chr19:37019181-37019889 Neighboring gene zinc finger protein 529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14527 Neighboring gene ZNF529 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14529 Neighboring gene zinc finger protein 382

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling. Debrus S, et al. Mol Cell Biol, 2005 Oct. PMID 16166646, Free PMC Article
    2. Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. Robertson NG, et al. Genomics, 1994 Sep 1. PMID 7829101
    3. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
    4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Luo J, et al. Cell, 2009 May 29. PMID 19490893, Free PMC Article
    5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zfp260 is a novel transcriptional regulator in normal and pathological heart development and a nuclear effector of alpha1-adrenergic signaling
      Title: The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 260
    Names
    zfp-260

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012756.3 → NP_001012774.1  zinc finger protein 260

      See identical proteins and their annotated locations for NP_001012774.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.
      Source sequence(s)
      AC092295, BC042676, DB283305
      Consensus CDS
      CCDS33003.1
      UniProtKB/Swiss-Prot
      Q0VF43, Q3ZCT1
      Related
      ENSP00000464964.1, ENST00000592282.1
      Conserved Domains (2) summary
      COG5048
      Location:25 → 406
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334 → 354
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001166036.2 → NP_001159508.1  zinc finger protein 260

      See identical proteins and their annotated locations for NP_001159508.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
      Source sequence(s)
      AC092295, BC119003, DB283305
      Consensus CDS
      CCDS33003.1
      UniProtKB/Swiss-Prot
      Q0VF43, Q3ZCT1
      Related
      ENSP00000467219.1, ENST00000588993.1
      Conserved Domains (2) summary
      COG5048
      Location:25 → 406
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334 → 354
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001166037.2 → NP_001159509.1  zinc finger protein 260

      See identical proteins and their annotated locations for NP_001159509.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
      Source sequence(s)
      AC092295, AK291442
      Consensus CDS
      CCDS33003.1
      UniProtKB/Swiss-Prot
      Q0VF43, Q3ZCT1
      Related
      ENSP00000429803.1, ENST00000523638.6
      Conserved Domains (2) summary
      COG5048
      Location:25 → 406
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334 → 354
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001166038.2 → NP_001159510.1  zinc finger protein 260

      See identical proteins and their annotated locations for NP_001159510.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
      Source sequence(s)
      AC092295, BQ938102, DB283305
      Consensus CDS
      CCDS33003.1
      UniProtKB/Swiss-Prot
      Q0VF43, Q3ZCT1
      Related
      ENSP00000465834.1, ENST00000593142.5
      Conserved Domains (2) summary
      COG5048
      Location:25 → 406
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334 → 354
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001375596.1 → NP_001362525.1  zinc finger protein 260

      Status: VALIDATED

      Source sequence(s)
      AC092295
      Consensus CDS
      CCDS33003.1
      UniProtKB/Swiss-Prot
      Q0VF43, Q3ZCT1
      Conserved Domains (2) summary
      COG5048
      Location:25 → 406
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334 → 354
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001375597.1 → NP_001362526.1  zinc finger protein 260

      Status: VALIDATED

      Source sequence(s)
      AC092295
      Consensus CDS
      CCDS33003.1
      UniProtKB/Swiss-Prot
      Q0VF43, Q3ZCT1
      Conserved Domains (2) summary
      COG5048
      Location:25 → 406
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334 → 354
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001375598.1 → NP_001362527.1  zinc finger protein 260

      Status: VALIDATED

      Source sequence(s)
      AC092295
      Consensus CDS
      CCDS33003.1
      UniProtKB/Swiss-Prot
      Q0VF43, Q3ZCT1
      Conserved Domains (2) summary
      COG5048
      Location:25 → 406
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334 → 354
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      36510687..36528271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026741.2 → XP_016882230.1  zinc finger protein 260 isoform X1

      UniProtKB/Swiss-Prot
      Q0VF43, Q3ZCT1
      Conserved Domains (2) summary
      COG5048
      Location:25 → 406
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334 → 354
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      39185915..39203539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320825.1 → XP_054176800.1  zinc finger protein 260 isoform X1

      UniProtKB/Swiss-Prot
      Q0VF43, Q3ZCT1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZCT1.3 GenPept UniProtKB/Swiss-Prot:Q3ZCT1

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