OXNAD1 oxidoreductase NAD binding domain containing 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OXNAD1provided by HGNC
Official Full Name: oxidoreductase NAD binding domain containing 1provided by HGNC
Primary source: HGNC:HGNC:25128
See related: Ensembl:ENSG00000154814 MIM:620581; AllianceGenome:HGNC:25128
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable oxidoreductase activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lymph node (RPKM 2.7), appendix (RPKM 1.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p25.1-p24.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (16265212..16352095)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (16266369..16353284)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (16306719..16393602)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HTP more info	PubMed

General protein information

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Preferred Names: oxidoreductase NAD-binding domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001330670.3 → NP_001317599.1 oxidoreductase NAD-binding domain-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC090953, BC007285

Consensus CDS

CCDS87053.1

UniProtKB/TrEMBL

B4DQJ7, C9JLB7, F5H620

Related

ENSP00000487136.1, ENST00000627468.2

Conserved Domains (1) summary

cd00322
Location:93 → 327

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
NM_001330671.3 → NP_001317600.1 oxidoreductase NAD-binding domain-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC090948, AC090953, CR739022

Consensus CDS

CCDS87053.1

UniProtKB/TrEMBL

B4DQJ7, C9JLB7, F5H620

Related

ENSP00000389872.2, ENST00000435829.6

Conserved Domains (1) summary

cd00322
Location:93 → 327

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
NM_001352977.2 → NP_001339906.1 oxidoreductase NAD-binding domain-containing protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC090948, AC090953, BQ180851

Consensus CDS

CCDS2630.1

UniProtKB/Swiss-Prot

Q2HYC7, Q59FA4, Q96HP4

UniProtKB/TrEMBL

U3KQU8

Related

ENSP00000476239.1, ENST00000606098.1

Conserved Domains (1) summary

cd00322
Location:75 → 309

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
NM_001352978.2 → NP_001339907.1 oxidoreductase NAD-binding domain-containing protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC090948, AC090953, CR739022

Consensus CDS

CCDS2630.1

UniProtKB/Swiss-Prot

Q2HYC7, Q59FA4, Q96HP4

UniProtKB/TrEMBL

U3KQU8

Related

ENSP00000475547.1, ENST00000605932.5

Conserved Domains (1) summary

cd00322
Location:75 → 309

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
NM_001352980.2 → NP_001339909.1 oxidoreductase NAD-binding domain-containing protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC090953, BC007285

UniProtKB/TrEMBL

U3KQU8

Conserved Domains (1) summary

cd00322
Location:48 → 282

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
NM_001352981.2 → NP_001339910.1 oxidoreductase NAD-binding domain-containing protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC090948, AC090953, BQ180851

UniProtKB/TrEMBL

U3KQU8

Conserved Domains (1) summary

cd00322
Location:48 → 282

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
NM_001352982.2 → NP_001339911.1 oxidoreductase NAD-binding domain-containing protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC090948, AC090953

UniProtKB/TrEMBL

U3KQU8

Conserved Domains (1) summary

cd00322
Location:48 → 282

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
NM_001352983.2 → NP_001339912.1 oxidoreductase NAD-binding domain-containing protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC090948, AC090953, CR739022

UniProtKB/TrEMBL

U3KQU8

Conserved Domains (1) summary

cd00322
Location:48 → 282

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
NM_138381.5 → NP_612390.1 oxidoreductase NAD-binding domain-containing protein 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_612390.1

Status: VALIDATED

Source sequence(s)

AC090953, BC007285, BC008322, HY044078

Consensus CDS

CCDS2630.1

UniProtKB/Swiss-Prot

Q2HYC7, Q59FA4, Q96HP4

UniProtKB/TrEMBL

U3KQU8

Related

ENSP00000285083.5, ENST00000285083.10

Conserved Domains (1) summary

cd00322
Location:75 → 309

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RNA

NR_148217.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC090948, AC090953, BQ180851
NR_148218.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC090948, AC090953, BQ180851
NR_148219.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC090948, AC090953, BQ180851
NR_148220.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC090948, AC090953, CR739022

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

16265212..16352095

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011534230.4 → XP_011532532.1 oxidoreductase NAD-binding domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_011532532.1

UniProtKB/TrEMBL

B4DQJ7

Conserved Domains (1) summary

cd00322
Location:148 → 382

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
XM_011534235.4 → XP_011532537.1 oxidoreductase NAD-binding domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_011532537.1

UniProtKB/TrEMBL

B4DQJ7

Conserved Domains (1) summary

cd00322
Location:148 → 382

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
XM_005265559.5 → XP_005265616.1 oxidoreductase NAD-binding domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_005265616.1

UniProtKB/TrEMBL

B4DQJ7

Conserved Domains (1) summary

cd00322
Location:148 → 382

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RNA

XR_007095766.1 RNA Sequence
XR_007095767.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

16266369..16353284

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054348411.1 → XP_054204386.1 oxidoreductase NAD-binding domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

B4DQJ7
XM_054348412.1 → XP_054204387.1 oxidoreductase NAD-binding domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

B4DQJ7
XM_054348413.1 → XP_054204388.1 oxidoreductase NAD-binding domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

B4DQJ7