MAST2 microtubule associated serine/threonine kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAST2provided by HGNC
Official Full Name: microtubule associated serine/threonine kinase 2provided by HGNC
Primary source: HGNC:HGNC:19035
See related: Ensembl:ENSG00000086015 MIM:612257; AllianceGenome:HGNC:19035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MTSSK; MAST205
Summary: Enables phosphatase binding activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted to be located in cytoplasm; cytoskeleton; and plasma membrane. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis (RPKM 25.4), heart (RPKM 11.8) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p34.1

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (45803612..46036122)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (45680810..45913311)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (46269284..46501794)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant.
Title: A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant.
MAST1 variant causes mega-corpus-callosum syndrome with cortical malformations but without cerebellar hypoplasia.
Title: MAST1 variant causes mega-corpus-callosum syndrome with cortical malformations but without cerebellar hypoplasia.
High MAST2 mRNA expression and its role in diagnosis and prognosis of liver cancer.
Title: High MAST2 mRNA expression and its role in diagnosis and prognosis of liver cancer.
we observed 3 case-specific duplications of the autosomal gene MAST2, and in a replication phase we found another 11 duplications
Title: A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans.
Viral and PTEN peptide interactions to MAST2-PDZ occur via a unique kinetic step which involves both canonical C-terminal PBM binding and N-terminal anchoring.
Title: Deciphering the unconventional peptide binding to the PDZ domain of MAST2.
MAST2 gene rearrangements occur in invasive breast carcinoma.
Title: MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions.
MAST205 plays an important role in regulating CFTR expression and function
Title: MAST205 competes with cystic fibrosis transmembrane conductance regulator (CFTR)-associated ligand for binding to CFTR to regulate CFTR-mediated fluid transport.
The MAST2 sequence at the 5' end of SVA(F1) acts as a positive transcriptional regulator in human germ cells.
Title: Transcriptional regulation of human-specific SVAF₁ retrotransposons by cis-regulatory MAST2 sequences.
Overexpression of MAST1 or MAST2 gene fusions has a proliferative effect both in vitro and in vivo in breast cancer cell lines.
Title: Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.
Recruitment of a MAST2 CpG island was most likely beneficial to the hybrid retrotransposons because it could significantly increase retrotransposition frequency.
Title: Novel family of human transposable elements formed due to fusion of the first exon of gene MAST2 with retrotransposon SVA.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-32364 (e-PCR)
- UniSTS:55824

SHGC-74779 (e-PCR)
- UniSTS:53020

SHGC-74768 (e-PCR)
- UniSTS:39476

RH67834 (e-PCR)
- UniSTS:71752

MAST2__7379 (e-PCR)
- UniSTS:466301

RH47223 (e-PCR)
- UniSTS:32920

AL009603 (e-PCR)
- UniSTS:2982

SHGC-30506 (e-PCR)
- UniSTS:20699

SHGC-147513 (e-PCR)
- UniSTS:175852

WI-21964 (e-PCR)
- UniSTS:13818

RH65021 (e-PCR)
- UniSTS:33279

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of interleukin-12 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatid differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microtubule-associated serine/threonine-protein kinase 2

Names: microtubule associated testis specific serine/threonine protein kinase

NP_001306174.1

EC 2.7.11.1

NP_001311249.1

EC 2.7.11.1

NP_001311250.1

EC 2.7.11.1

NP_055927.2

EC 2.7.11.1

XP_005270712.1

EC 2.7.11.1

XP_005270713.1

EC 2.7.11.1

XP_006710540.1

EC 2.7.11.1

XP_011539361.1

EC 2.7.11.1

XP_011539363.1

EC 2.7.11.1

XP_011539364.1

EC 2.7.11.1

XP_011539365.1

EC 2.7.11.1

XP_011539366.1

EC 2.7.11.1

XP_011539369.1

EC 2.7.11.1

XP_011539370.1

EC 2.7.11.1

XP_011539371.1

EC 2.7.11.1

XP_016856241.1

EC 2.7.11.1

XP_016856242.1

EC 2.7.11.1

XP_016856244.1

EC 2.7.11.1

XP_047306052.1

EC 2.7.11.1

XP_047306061.1

EC 2.7.11.1

XP_047306067.1

EC 2.7.11.1

XP_047306072.1

EC 2.7.11.1

XP_047306077.1

EC 2.7.11.1

XP_047306078.1

EC 2.7.11.1

XP_047306079.1

EC 2.7.11.1

XP_047306085.1

EC 2.7.11.1

XP_047306086.1

EC 2.7.11.1

XP_047306094.1

EC 2.7.11.1

XP_047306097.1

EC 2.7.11.1

XP_047306098.1

EC 2.7.11.1

XP_047306101.1

EC 2.7.11.1

XP_047306105.1

EC 2.7.11.1

XP_047306106.1

EC 2.7.11.1

XP_047306109.1

EC 2.7.11.1

XP_054191305.1

EC 2.7.11.1

XP_054191306.1

EC 2.7.11.1

XP_054191307.1

EC 2.7.11.1

XP_054191308.1

EC 2.7.11.1

XP_054191309.1

EC 2.7.11.1

XP_054191310.1

EC 2.7.11.1

XP_054191311.1

EC 2.7.11.1

XP_054191312.1

EC 2.7.11.1

XP_054191313.1

EC 2.7.11.1

XP_054191314.1

EC 2.7.11.1

XP_054191315.1

EC 2.7.11.1

XP_054191316.1

EC 2.7.11.1

XP_054191317.1

EC 2.7.11.1

XP_054191318.1

EC 2.7.11.1

XP_054191319.1

EC 2.7.11.1

XP_054191320.1

EC 2.7.11.1

XP_054191321.1

EC 2.7.11.1

XP_054191322.1

EC 2.7.11.1

XP_054191323.1

EC 2.7.11.1

XP_054191324.1

EC 2.7.11.1

XP_054191325.1

EC 2.7.11.1

XP_054191326.1

EC 2.7.11.1

XP_054191327.1

EC 2.7.11.1

XP_054191328.1

EC 2.7.11.1

XP_054191329.1

EC 2.7.11.1

XP_054191330.1

EC 2.7.11.1

XP_054191331.1

EC 2.7.11.1

XP_054191332.1

EC 2.7.11.1

XP_054191333.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001319245.2 → NP_001306174.1 microtubule-associated serine/threonine-protein kinase 2 isoform 2

Status: VALIDATED

Source sequence(s)

AB047005, AL358075, AL603882, BC065499

UniProtKB/Swiss-Prot

Q6P0Q8

Conserved Domains (4) summary

smart00220
Location:512 → 785

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1105 → 1186

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:511 → 790

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:201 → 475

DUF1908; Domain of unknown function (DUF1908)
NM_001324320.2 → NP_001311249.1 microtubule-associated serine/threonine-protein kinase 2 isoform 3

Status: VALIDATED

Source sequence(s)

AL358075, AL603882, AL603888, AL645480

Conserved Domains (4) summary

smart00220
Location:519 → 792

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1112 → 1193

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:518 → 797

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:201 → 482

DUF1908; Domain of unknown function (DUF1908)
NM_001324321.2 → NP_001311250.1 microtubule-associated serine/threonine-protein kinase 2 isoform 4

Status: VALIDATED

Source sequence(s)

AL358075, AL603888, AL645480

Conserved Domains (4) summary

smart00220
Location:358 → 631

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:951 → 1032

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:357 → 636

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:40 → 321

DUF1908; Domain of unknown function (DUF1908)
NM_015112.3 → NP_055927.2 microtubule-associated serine/threonine-protein kinase 2 isoform 1

Status: VALIDATED

Source sequence(s)

AB047005, AL540100, AL603882, BC065499, CN297081

Consensus CDS

CCDS41326.1

UniProtKB/Swiss-Prot

O94899, Q5VT07, Q5VT08, Q6P0Q8, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8

Related

ENSP00000354671.2, ENST00000361297.7

Conserved Domains (4) summary

smart00220
Location:512 → 785

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1105 → 1186

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:511 → 790

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:201 → 475

DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

45803612..46036122

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011541059.3 → XP_011539361.1 microtubule-associated serine/threonine-protein kinase 2 isoform X1

Conserved Domains (4) summary

smart00220
Location:584 → 857

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1177 → 1258

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:583 → 862

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:266 → 547

DUF1908; Domain of unknown function (DUF1908)
XM_011541069.3 → XP_011539371.1 microtubule-associated serine/threonine-protein kinase 2 isoform X24

Conserved Domains (4) summary

smart00220
Location:584 → 857

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1177 → 1258

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:583 → 862

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:266 → 547

DUF1908; Domain of unknown function (DUF1908)
XM_011541061.3 → XP_011539363.1 microtubule-associated serine/threonine-protein kinase 2 isoform X2

Conserved Domains (4) summary

smart00220
Location:584 → 857

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1177 → 1258

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:583 → 862

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:266 → 547

DUF1908; Domain of unknown function (DUF1908)
XM_047450141.1 → XP_047306097.1 microtubule-associated serine/threonine-protein kinase 2 isoform X25
XM_011541062.3 → XP_011539364.1 microtubule-associated serine/threonine-protein kinase 2 isoform X3

Conserved Domains (4) summary

smart00220
Location:577 → 850

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1170 → 1251

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:576 → 855

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:266 → 540

DUF1908; Domain of unknown function (DUF1908)
XM_047450142.1 → XP_047306098.1 microtubule-associated serine/threonine-protein kinase 2 isoform X26
XM_047450096.1 → XP_047306052.1 microtubule-associated serine/threonine-protein kinase 2 isoform X4
XM_047450145.1 → XP_047306101.1 microtubule-associated serine/threonine-protein kinase 2 isoform X27
XM_047450111.1 → XP_047306067.1 microtubule-associated serine/threonine-protein kinase 2 isoform X8
XM_047450149.1 → XP_047306105.1 microtubule-associated serine/threonine-protein kinase 2 isoform X28
XM_047450150.1 → XP_047306106.1 microtubule-associated serine/threonine-protein kinase 2 isoform X29
XM_047450153.1 → XP_047306109.1 microtubule-associated serine/threonine-protein kinase 2 isoform X30
XM_047450105.1 → XP_047306061.1 microtubule-associated serine/threonine-protein kinase 2 isoform X7
XM_047450121.1 → XP_047306077.1 microtubule-associated serine/threonine-protein kinase 2 isoform X10
XM_047450123.1 → XP_047306079.1 microtubule-associated serine/threonine-protein kinase 2 isoform X12
XM_047450129.1 → XP_047306085.1 microtubule-associated serine/threonine-protein kinase 2 isoform X13
XM_011541064.3 → XP_011539366.1 microtubule-associated serine/threonine-protein kinase 2 isoform X6

Conserved Domains (4) summary

smart00220
Location:531 → 804

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1124 → 1205

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:530 → 809

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:213 → 494

DUF1908; Domain of unknown function (DUF1908)
XM_047450116.1 → XP_047306072.1 microtubule-associated serine/threonine-protein kinase 2 isoform X9
XM_047450122.1 → XP_047306078.1 microtubule-associated serine/threonine-protein kinase 2 isoform X11
XM_011541063.2 → XP_011539365.1 microtubule-associated serine/threonine-protein kinase 2 isoform X5

Conserved Domains (4) summary

smart00220
Location:534 → 807

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1127 → 1208

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:533 → 812

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:216 → 497

DUF1908; Domain of unknown function (DUF1908)
XM_017000752.2 → XP_016856241.1 microtubule-associated serine/threonine-protein kinase 2 isoform X14
XM_017000755.2 → XP_016856244.1 microtubule-associated serine/threonine-protein kinase 2 isoform X19
XM_047450130.1 → XP_047306086.1 microtubule-associated serine/threonine-protein kinase 2 isoform X17
XM_005270655.4 → XP_005270712.1 microtubule-associated serine/threonine-protein kinase 2 isoform X15

Conserved Domains (4) summary

smart00220
Location:434 → 707

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1027 → 1108

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:433 → 712

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:116 → 397

DUF1908; Domain of unknown function (DUF1908)
XM_006710477.4 → XP_006710540.1 microtubule-associated serine/threonine-protein kinase 2 isoform X20

UniProtKB/TrEMBL

A0A669KBJ4

Related

ENSP00000501318.1, ENST00000674079.1

Conserved Domains (4) summary

smart00220
Location:369 → 642

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:962 → 1043

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:368 → 647

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:51 → 332

DUF1908; Domain of unknown function (DUF1908)
XM_017000753.2 → XP_016856242.1 microtubule-associated serine/threonine-protein kinase 2 isoform X18
XM_047450138.1 → XP_047306094.1 microtubule-associated serine/threonine-protein kinase 2 isoform X23
XM_005270656.6 → XP_005270713.1 microtubule-associated serine/threonine-protein kinase 2 isoform X16

Conserved Domains (4) summary

smart00220
Location:425 → 698

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1018 → 1099

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:424 → 703

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:107 → 388

DUF1908; Domain of unknown function (DUF1908)
XM_011541067.3 → XP_011539369.1 microtubule-associated serine/threonine-protein kinase 2 isoform X21

Conserved Domains (4) summary

smart00220
Location:357 → 630

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:950 → 1031

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:356 → 635

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:39 → 320

DUF1908; Domain of unknown function (DUF1908)
XM_011541068.2 → XP_011539370.1 microtubule-associated serine/threonine-protein kinase 2 isoform X22

Conserved Domains (4) summary

smart00220
Location:350 → 623

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:943 → 1024

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:349 → 628

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:39 → 313

DUF1908; Domain of unknown function (DUF1908)

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

45680810..45913311

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054335330.1 → XP_054191305.1 microtubule-associated serine/threonine-protein kinase 2 isoform X1
XM_054335352.1 → XP_054191327.1 microtubule-associated serine/threonine-protein kinase 2 isoform X24
XM_054335331.1 → XP_054191306.1 microtubule-associated serine/threonine-protein kinase 2 isoform X2
XM_054335353.1 → XP_054191328.1 microtubule-associated serine/threonine-protein kinase 2 isoform X25
XM_054335332.1 → XP_054191307.1 microtubule-associated serine/threonine-protein kinase 2 isoform X3
XM_054335354.1 → XP_054191329.1 microtubule-associated serine/threonine-protein kinase 2 isoform X26
XM_054335333.1 → XP_054191308.1 microtubule-associated serine/threonine-protein kinase 2 isoform X4
XM_054335355.1 → XP_054191330.1 microtubule-associated serine/threonine-protein kinase 2 isoform X27
XM_054335337.1 → XP_054191312.1 microtubule-associated serine/threonine-protein kinase 2 isoform X8
XM_054335356.1 → XP_054191331.1 microtubule-associated serine/threonine-protein kinase 2 isoform X28
XM_054335357.1 → XP_054191332.1 microtubule-associated serine/threonine-protein kinase 2 isoform X29
XM_054335358.1 → XP_054191333.1 microtubule-associated serine/threonine-protein kinase 2 isoform X30
XM_054335336.1 → XP_054191311.1 microtubule-associated serine/threonine-protein kinase 2 isoform X7
XM_054335339.1 → XP_054191314.1 microtubule-associated serine/threonine-protein kinase 2 isoform X10
XM_054335341.1 → XP_054191316.1 microtubule-associated serine/threonine-protein kinase 2 isoform X12
XM_054335342.1 → XP_054191317.1 microtubule-associated serine/threonine-protein kinase 2 isoform X13
XM_054335335.1 → XP_054191310.1 microtubule-associated serine/threonine-protein kinase 2 isoform X6
XM_054335338.1 → XP_054191313.1 microtubule-associated serine/threonine-protein kinase 2 isoform X9
XM_054335340.1 → XP_054191315.1 microtubule-associated serine/threonine-protein kinase 2 isoform X11
XM_054335334.1 → XP_054191309.1 microtubule-associated serine/threonine-protein kinase 2 isoform X5
XM_054335343.1 → XP_054191318.1 microtubule-associated serine/threonine-protein kinase 2 isoform X14
XM_054335348.1 → XP_054191323.1 microtubule-associated serine/threonine-protein kinase 2 isoform X19
XM_054335344.1 → XP_054191319.1 microtubule-associated serine/threonine-protein kinase 2 isoform X15
XM_054335346.1 → XP_054191321.1 microtubule-associated serine/threonine-protein kinase 2 isoform X17
XM_054335349.1 → XP_054191324.1 microtubule-associated serine/threonine-protein kinase 2 isoform X20
XM_054335347.1 → XP_054191322.1 microtubule-associated serine/threonine-protein kinase 2 isoform X18
XM_054335345.1 → XP_054191320.1 microtubule-associated serine/threonine-protein kinase 2 isoform X16
XM_054335350.1 → XP_054191325.1 microtubule-associated serine/threonine-protein kinase 2 isoform X21
XM_054335351.1 → XP_054191326.1 microtubule-associated serine/threonine-protein kinase 2 isoform X22