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    MRPL9 mitochondrial ribosomal protein L9 [ Homo sapiens (human) ]

    Gene ID: 65005, updated on 10-Dec-2024

    Summary

    Official Symbol
    MRPL9provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L9provided by HGNC
    Primary source
    HGNC:HGNC:14277
    See related
    Ensembl:ENSG00000143436 MIM:611824; AllianceGenome:HGNC:14277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L9mt; bL9m
    Summary
    This is a nuclear gene encoding a protein component of the 39S subunit of the mitochondrial ribosome. Alternative splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in bone marrow (RPKM 15.0), lymph node (RPKM 13.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MRPL9 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151759647..151763496, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150883033..150886885, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151732123..151735972, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 662, pseudogene Neighboring gene ribosomal protein S11 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1724 Neighboring gene ornithine decarboxylase antizyme 3 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:151741546-151742242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:151742243-151742937 Neighboring gene tudor and KH domain containing Neighboring gene chloride nucleotide-sensitive channel 1A pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1326 Neighboring gene TDRKH antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  
    part_of mitochondrial large ribosomal subunit PubMed 
    part_of mitochondrial large ribosomal subunit PubMed 
    located_in mitochondrial ribosome PubMed 
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    large ribosomal subunit protein bL9m
    Names
    39S ribosomal protein L9, mitochondrial
    mitochondrial large ribosomal subunit protein bL9m

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300733.2 → NP_001287662.1  large ribosomal subunit protein bL9m isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AW452832, BC004517, CF127136
      Consensus CDS
      CCDS72916.1
      UniProtKB/TrEMBL
      Q5SZR1
      Related
      ENSP00000357822.3, ENST00000368829.3
      Conserved Domains (1) summary
      pfam01281
      Location:95 → 140
      Ribosomal_L9_N; Ribosomal protein L9, N-terminal domain
    2. NM_031420.4 → NP_113608.1  large ribosomal subunit protein bL9m isoform 1

      See identical proteins and their annotated locations for NP_113608.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AW452832, BC004517
      Consensus CDS
      CCDS1003.1
      UniProtKB/Swiss-Prot
      B2RD99, Q5SZR2, Q9BSW8, Q9BYD2
      Related
      ENSP00000357823.3, ENST00000368830.8
      Conserved Domains (2) summary
      PRK00137
      Location:95 → 225
      rplI; 50S ribosomal protein L9; Reviewed
      pfam01281
      Location:95 → 140
      Ribosomal_L9_N; Ribosomal protein L9, N-terminal domain

    RNA

    1. NR_125331.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5' most expected start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK026363, BC004517
      Related
      ENST00000467306.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      151759647..151763496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_921910.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      150883033..150886885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008486151.1 RNA Sequence

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