U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    CST7 cystatin F [ Homo sapiens (human) ]

    Gene ID: 8530, updated on 10-Dec-2024

    Summary

    Official Symbol
    CST7provided by HGNC
    Official Full Name
    cystatin Fprovided by HGNC
    Primary source
    HGNC:HGNC:2479
    See related
    Ensembl:ENSG00000077984 MIM:603253; AllianceGenome:HGNC:2479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CMAP
    Summary
    The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 321.5), spleen (RPKM 27.1) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CST7 in Genome Data Viewer
    Location:
    20p11.21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (24949269..24959928)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (25013382..25024201)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (24929905..24940564)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904881 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:24881363-24881542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12737 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:24899137-24899770 Neighboring gene long intergenic non-protein coding RNA 2967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17653 Neighboring gene RNA, U6 small nuclear 1257, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:24960021-24960521 Neighboring gene adipocyte plasma membrane associated protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:24961283-24961783 Neighboring gene H3K27ac hESC enhancers GRCh37_chr20:24972940-24973440 and GRCh37_chr20:24973441-24973941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17657 Neighboring gene acyl-CoA synthetase short chain family member 1 Neighboring gene Sharpr-MPRA regulatory region 14776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:25038651-25039256

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus PubMed 
    located_in cytoplasmic vesicle PubMed 
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum PubMed 
    located_in endosome PubMed 
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    is_active_in late endosome  
    is_active_in lysosome  
    located_in lysosome PubMed 
    located_in multivesicular body PubMed 

    General protein information

    Preferred Names
    cystatin-F
    Names
    cystatin-7
    cystatin-like metastasis-associated protein
    leukocystatin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003650.4NP_003641.3  cystatin-F precursor

      See identical proteins and their annotated locations for NP_003641.3

      Status: REVIEWED

      Source sequence(s)
      AF031824, BG547285, CA449286
      Consensus CDS
      CCDS13165.2
      UniProtKB/Swiss-Prot
      O76096, Q6FH95, Q7Z4J8, Q9UED4
      Related
      ENSP00000420384.1, ENST00000480798.2
      Conserved Domains (1) summary
      smart00043
      Location:36145
      CY; Cystatin-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      24949269..24959928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      25013382..25024201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.