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    OXTR oxytocin receptor [ Homo sapiens (human) ]

    Gene ID: 5021, updated on 27-Dec-2024

    Summary

    Official Symbol
    OXTRprovided by HGNC
    Official Full Name
    oxytocin receptorprovided by HGNC
    Primary source
    HGNC:HGNC:8529
    See related
    Ensembl:ENSG00000180914 MIM:167055; AllianceGenome:HGNC:8529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OTR; OT-R
    Summary
    The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in ovary (RPKM 1.0), endometrium (RPKM 1.0) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See OXTR in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (8741269..8769613, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (8741551..8760789, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (8792067..8811299, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:8664536-8665156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19390 Neighboring gene ssu-2 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19393 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14028 Neighboring gene olfactory receptor family 7 subfamily E member 122 pseudogene Neighboring gene MPRA-validated peak4531 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr3:8765327-8765828 Neighboring gene caveolin 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:8808751-8809422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14029 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:8810095-8810766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19394 Neighboring gene uncharacterized LOC107986061 Neighboring gene uncharacterized LOC107984112

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ionotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxytocin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables vasopressin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in digestive tract development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in estrous cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in maternal behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maternal process involved in parturition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of norepinephrine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of penile erection IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of uterine smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vasoconstriction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of systemic arterial blood pressure by vasopressin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to anoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cytokine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in social behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sperm ejaculation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in suckling behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in telencephalon development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000916.4NP_000907.2  oxytocin receptor

      See identical proteins and their annotated locations for NP_000907.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 all encode the same protein.
      Source sequence(s)
      AC068312
      Consensus CDS
      CCDS2570.1
      UniProtKB/Swiss-Prot
      P30559, Q15071
      UniProtKB/TrEMBL
      B2R9L7
      Related
      ENSP00000324270.2, ENST00000316793.8
      Conserved Domains (1) summary
      cd15387
      Location:40340
      7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001354653.2NP_001341582.1  oxytocin receptor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same protein.
      Source sequence(s)
      AC068312
      Consensus CDS
      CCDS2570.1
      UniProtKB/Swiss-Prot
      P30559, Q15071
      UniProtKB/TrEMBL
      B2R9L7
      Conserved Domains (1) summary
      cd15387
      Location:40340
      7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001354654.2NP_001341583.1  oxytocin receptor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same protein.
      Source sequence(s)
      AC068312
      Consensus CDS
      CCDS2570.1
      UniProtKB/Swiss-Prot
      P30559, Q15071
      UniProtKB/TrEMBL
      B2R9L7
      Conserved Domains (1) summary
      cd15387
      Location:40340
      7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_001354655.2NP_001341584.1  oxytocin receptor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same protein.
      Source sequence(s)
      AC068312
      Consensus CDS
      CCDS2570.1
      UniProtKB/Swiss-Prot
      P30559, Q15071
      UniProtKB/TrEMBL
      B2R9L7
      Conserved Domains (1) summary
      cd15387
      Location:40340
      7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. NM_001354656.3NP_001341585.1  oxytocin receptor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same protein.
      Source sequence(s)
      AC068312
      Consensus CDS
      CCDS2570.1
      UniProtKB/Swiss-Prot
      P30559, Q15071
      UniProtKB/TrEMBL
      B2R9L7
      Conserved Domains (1) summary
      cd15387
      Location:40340
      7tmA_OT_R; oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      8741269..8769613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007095681.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      8741551..8760789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)