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    INHBA inhibin subunit beta A [ Homo sapiens (human) ]

    Gene ID: 3624, updated on 10-Dec-2024

    Summary

    Official Symbol
    INHBAprovided by HGNC
    Official Full Name
    inhibin subunit beta Aprovided by HGNC
    Primary source
    HGNC:HGNC:6066
    See related
    Ensembl:ENSG00000122641 MIM:147290; AllianceGenome:HGNC:6066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EDF; FRP
    Summary
    This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]
    Expression
    Broad expression in endometrium (RPKM 12.3), gall bladder (RPKM 11.3) and 15 other tissues See more
    Orthologs
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    Genomic context

    See INHBA in Genome Data Viewer
    Location:
    7p14.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (41685114..41705406, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (41843512..41867440, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (41724712..41742688, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375247 Neighboring gene uncharacterized LOC107986789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25899 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:41748736-41749935 Neighboring gene INHBA antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25901 Neighboring gene uncharacterized LOC124901618 Neighboring gene GLI family zinc finger 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:42068797-42069297 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:42105443-42106096 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:42131129-42131824 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (14 hits/1271 screens)

    EBI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog
    Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.
    EBI GWAS Catalog
    Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of inhibin, beta A (INHBA) in human B cells PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of inhibin, beta A (INHBA) in peptide-treated PBMCs PubMed
    Tat tat HIV-1 Tat upregulates the expression of inhibin, beta A (INHBA) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • AC005027.3

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity PubMed 
    enables growth factor activity PubMed 
    enables hormone activity PubMed 
    enables identical protein binding PubMed 
    enables peptide hormone binding PubMed 
    enables protein binding PubMed 
    enables protein-containing complex binding  
    enables type II activin receptor binding PubMed 
    Items 1 - 25 of 60
    Process Evidence Code Pubs
    involved_in GABAergic neuron differentiation PubMed 
    involved_in SMAD protein signal transduction  
    involved_in Sertoli cell differentiation  
    involved_in activin receptor signaling pathway PubMed 
    involved_in androgen metabolic process  
    involved_in androst-4-ene-3,17-dione biosynthetic process  
    involved_in autophagy  
    involved_in cardiac fibroblast cell development  
    involved_in cell differentiation PubMed 
    involved_in cell surface receptor signaling pathway PubMed 
    involved_in cell-cell signaling PubMed 
    involved_in cellular response to angiotensin  
    involved_in cellular response to cholesterol  
    involved_in cellular response to follicle-stimulating hormone stimulus  
    involved_in cellular response to hypoxia  
    involved_in cellular response to oxygen-glucose deprivation  
    involved_in cytokine-mediated signaling pathway  
    involved_in defense response PubMed 
    involved_in endodermal cell differentiation PubMed 
    involved_in erythrocyte differentiation PubMed 
    involved_in extrinsic apoptotic signaling pathway PubMed 
    involved_in eyelid development in camera-type eye  
    involved_in hair follicle development PubMed 
    involved_in hematopoietic progenitor cell differentiation PubMed 
    involved_in hemoglobin biosynthetic process PubMed 
    involved_in male gonad development PubMed 
    involved_in mesodermal cell differentiation  
    involved_in negative regulation of B cell differentiation PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle PubMed 
    involved_in negative regulation of cell growth PubMed 
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of follicle-stimulating hormone secretion PubMed 
    involved_in negative regulation of macrophage differentiation PubMed 
    involved_in negative regulation of phosphorylation PubMed 
    involved_in negative regulation of type II interferon production PubMed 
    involved_in nervous system development PubMed 
    involved_in odontogenesis PubMed 
    involved_in ovarian follicle development PubMed 
    involved_in ovarian follicle development PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of SMAD protein signal transduction PubMed 
    involved_in positive regulation of collagen biosynthetic process  
    involved_in positive regulation of erythrocyte differentiation PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand PubMed 
    involved_in positive regulation of follicle-stimulating hormone secretion PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of ovulation  
    involved_in positive regulation of protein metabolic process PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase III  
    involved_in progesterone secretion PubMed 
    involved_in regulation of follicle-stimulating hormone secretion PubMed 
    involved_in regulation of transcription by RNA polymerase II PubMed 
    involved_in response to aldosterone  
    NOT involved_in response to wounding PubMed 
    involved_in roof of mouth development PubMed 
    involved_in striatal medium spiny neuron differentiation PubMed 
    involved_in testosterone biosynthetic process  
    involved_in transcription by RNA polymerase II  
    Items 1 - 25 of 60
    Component Evidence Code Pubs
    part_of activin A complex PubMed 
    part_of enzyme activator complex PubMed 
    located_in extracellular region PubMed 
    located_in extracellular region  
    is_active_in extracellular space  
    part_of inhibin A complex PubMed 
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    inhibin beta A chain
    Names
    FSH-releasing protein
    Inhibin, beta-1
    activin beta-A chain
    erythroid differentiation factor
    erythroid differentiation protein
    follicle-stimulating hormone-releasing protein
    inhibin beta A subunit
    inhibin, beta A (activin A, activin AB alpha polypeptide)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002192.4 → NP_002183.1  inhibin beta A chain preproprotein

      See identical proteins and their annotated locations for NP_002183.1

      Status: REVIEWED

      Source sequence(s)
      AA491465, AC005027, AK001903, AU137531, BC007858
      Consensus CDS
      CCDS5464.1
      UniProtKB/Swiss-Prot
      P08476, Q14599
      UniProtKB/TrEMBL
      A4D1W7, Q53H39, Q9HBP0
      Related
      ENSP00000242208.4, ENST00000242208.5
      Conserved Domains (2) summary
      cd19404
      Location:319 → 426
      TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins
      cl02928
      Location:56 → 236
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      41685114..41705406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012174.2 → XP_016867663.2  inhibin beta A chain isoform X1

      UniProtKB/Swiss-Prot
      P08476, Q14599
      UniProtKB/TrEMBL
      A4D1W7, Q53H39, Q9HBP0
      Related
      ENSP00000490646.1, ENST00000638023.1
    2. XM_047420335.1 → XP_047276291.1  inhibin beta A chain isoform X1

      UniProtKB/Swiss-Prot
      P08476, Q14599
      UniProtKB/TrEMBL
      A4D1W7, Q53H39, Q9HBP0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      41843512..41867440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358159.1 → XP_054214134.1  inhibin beta A chain isoform X3

      UniProtKB/TrEMBL
      Q53H39, Q9HBP0
    2. XM_054358157.1 → XP_054214132.1  inhibin beta A chain isoform X2

    3. XM_054358158.1 → XP_054214133.1  inhibin beta A chain isoform X2

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