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    ARF4 ARF GTPase 4 [ Homo sapiens (human) ]

    Gene ID: 378, updated on 10-Dec-2024

    Summary

    Official Symbol
    ARF4provided by HGNC
    Official Full Name
    ARF GTPase 4provided by HGNC
    Primary source
    HGNC:HGNC:655
    See related
    Ensembl:ENSG00000168374 MIM:601177; AllianceGenome:HGNC:655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARF2
    Summary
    This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in gall bladder (RPKM 100.9), placenta (RPKM 94.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See ARF4 in Genome Data Viewer
    Location:
    3p14.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (57571363..57597344, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (57611733..57637720, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (57557090..57583071, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 12 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:57529659-57530209 Neighboring gene RNA, U6 small nuclear 108, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:57543831-57544463 Neighboring gene RNA, U6 small nuclear 483, pseudogene Neighboring gene phosphodiesterase 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19989 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:57582608-57583807 Neighboring gene ARF4 antisense RNA 1 Neighboring gene RNA, U6atac small nuclear 26, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 4 (ARF4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 4 (ARF4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 4 (ARF4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ADP-ribosylation factor 4 (ARF4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in apical protein localization  
    involved_in cell migration PubMed 
    involved_in cilium assembly  
    acts_upstream_of_or_within dendritic spine development PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity  
    involved_in intracellular protein transport  
    involved_in learning  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in protein localization to cilium  
    involved_in regulation of cilium assembly PubMed 
    involved_in regulation of postsynapse organization  
    involved_in regulation of reactive oxygen species metabolic process PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  
    involved_in vesicle-mediated transport  
    Component Evidence Code Pubs
    located_in Golgi membrane PubMed 
    is_active_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in dendritic spine PubMed 
    located_in extracellular exosome PubMed 
    located_in glutamatergic synapse  
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in ruffle membrane PubMed 

    General protein information

    Preferred Names
    ADP-ribosylation factor 4
    Names
    ADP ribosylation factor 4
    ADP-ribosylation factor 2
    NP_001651.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001660.4 → NP_001651.1  ADP-ribosylation factor 4

      See identical proteins and their annotated locations for NP_001651.1

      Status: REVIEWED

      Source sequence(s)
      BC003364, DA259855
      Consensus CDS
      CCDS2884.1
      UniProtKB/Swiss-Prot
      B2R7J7, P18085, P21371
      Related
      ENSP00000306010.6, ENST00000303436.11
      Conserved Domains (1) summary
      cl40481
      Location:1 → 180
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      57571363..57597344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      57611733..57637720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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