EIF4A1 eukaryotic translation initiation factor 4A1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: EIF4A1provided by HGNC
Official Full Name: eukaryotic translation initiation factor 4A1provided by HGNC
Primary source: HGNC:HGNC:3282
See related: Ensembl:ENSG00000161960 MIM:602641; AllianceGenome:HGNC:3282
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DDX2A; EIF4A; EIF-4A; eIF4A-I; eIF-4A-I
Summary: Enables double-stranded RNA binding activity and translation initiation factor activity. Involved in cytoplasmic translational initiation and positive regulation of transcription by RNA polymerase II. Located in nuclear stress granule; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in appendix (RPKM 182.3), bone marrow (RPKM 177.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (7572825..7579006)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (7477072..7483254)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (7476143..7482324)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic evidence supporting potential causal roles of EIF4 family in breast cancer: a two-sample randomized Mendelian study.
Title: Genetic evidence supporting potential causal roles of EIF4 family in breast cancer: a two-sample randomized Mendelian study.
mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3[IBTK]-mediated ubiquitination of eIF4A1 in cancer cells.
Title: mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3(IBTK)-mediated ubiquitination of eIF4A1 in cancer cells.
eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.
Title: eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.
eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma.
Title: eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma.
eIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a Triple-Negative Breast Cancer Cell Model.
Title: eIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a Triple-Negative Breast Cancer Cell Model.
Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer.
Title: Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer.
Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules.
Title: Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules.
High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.
Title: High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.
Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.
Title: Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.
The mRNA helicase eIF4A1 is involved in unwinding the G4 in the 5'-UTR of CtlP mRNA through its cooperation with ALC1.
Title: ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A1 (EIF4A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A1 (EIF4A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A1 (EIF4A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A1 (EIF4A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A004D02 (e-PCR)
- UniSTS:8227

RH11592 (e-PCR)
- UniSTS:87346

A005T43 (e-PCR)
- UniSTS:37201

RH11637 (e-PCR)
- UniSTS:84642

SHGC-31951 (e-PCR)
- UniSTS:27312

RH47184 (e-PCR)
- UniSTS:29104

G66079 (e-PCR)
- UniSTS:230070

RH36626 (e-PCR)
- UniSTS:19900

G66086 (e-PCR)
- UniSTS:230077

Readthrough SENP3-EIF4A1

Readthrough gene: SENP3-EIF4A1, Included gene: SENP3

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	HDA more info	PubMed
enables RNA cap binding	TAS Traceable Author Statement more info	PubMed
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables helicase activity	TAS Traceable Author Statement more info	PubMed
enables mRNA binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation factor activity, RNA binding	TAS Traceable Author Statement more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational initiation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic translation initiation factor 4F complex	NAS Non-traceable Author Statement more info	PubMed
part_of eukaryotic translation initiation factor 4F complex	TAS Traceable Author Statement more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nuclear stress granule	IDA Inferred from Direct Assay more info	PubMed
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eukaryotic initiation factor 4A-I

Names: ATP-dependent RNA helicase eIF4A-1; eukaryotic initiation factor 4AI; eukaryotic translation initiation factor 4A

NP_001191439.1

EC 3.6.4.13

NP_001407.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204510.2 → NP_001191439.1 eukaryotic initiation factor 4A-I isoform 2

See identical proteins and their annotated locations for NP_001191439.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1, resulting in an isoform (2) with a distinct and shorter C-terminus, compared to isoform 1.

Source sequence(s)

AA446856, AC016876, BC006210, BG284868

Consensus CDS

CCDS58511.1

UniProtKB/TrEMBL

J3KT12

Related

ENSP00000463486.1, ENST00000577269.5

Conserved Domains (1) summary

cl26939
Location:20 → 334

DEXDc; DEAD-like helicases superfamily
NM_001416.4 → NP_001407.1 eukaryotic initiation factor 4A-I isoform 1

See identical proteins and their annotated locations for NP_001407.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AA446856, AC016876, BG284868

Consensus CDS

CCDS11113.1

UniProtKB/Swiss-Prot

B2R6L8, D3DTP9, J3QLC4, P04765, P60842, Q5U018, Q61516

UniProtKB/TrEMBL

A8K088, A8K7F6

Related

ENSP00000293831.8, ENST00000293831.13

Conserved Domains (1) summary

PTZ00424
Location:20 → 406

PTZ00424; helicase 45; Provisional