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    SQE3 squalene epoxidase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829932, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SQE3
    Official Full Name
    squalene epoxidase 3
    Primary source
    TAIR:AT4G37760
    Locus tag
    AT4G37760
    See related
    Araport:AT4G37760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    squalene epoxidase 3; T28I19.40; T28I19_40
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    Genomic context

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    See SQE3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (17743738..17746697)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene 1-amino-cyclopropane-1-carboxylate synthase 8 Neighboring gene myb domain protein 87

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis Squalene Epoxidase 3 (SQE3) Complements SQE1 and Is Important for Embryo Development and Bulk Squalene Epoxidase Activity. Laranjeira S, et al. Mol Plant, 2015 Jul. PMID 25707755
    2. Arabidopsis thaliana squalene epoxidase 1 is essential for root and seed development. Rasbery JM, et al. J Biol Chem, 2007 Jun 8. PMID 17426032
    3. An example of intron junctional sliding in the gene families encoding squalene monooxygenase homologues in Arabidopsis thaliana and Brassica napus. Schäfer UA, et al. Plant Mol Biol, 1999 Mar. PMID 10350086
    4. Expression profiling reveals COI1 to be a key regulator of genes involved in wound- and methyl jasmonate-induced secondary metabolism, defence, and hormone interactions. Devoto A, et al. Plant Mol Biol, 2005 Jul. PMID 16021335
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SQE1 and SQE3 seem to be two functionally unequal redundant genes in the promotion of plant SQE activity in Arabidopsis
      Title: Arabidopsis Squalene Epoxidase 3 (SQE3) Complements SQE1 and Is Important for Embryo Development and Bulk Squalene Epoxidase Activity.
    2. isolated and characterized Arabidopsis sqe1 mutants and discovered severe developmental defects, including reduced root and hypocotyl elongation
      Title: Arabidopsis thaliana squalene epoxidase 1 is essential for root and seed development.
    Submit: New GeneRIF Correction

    General gene information

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    NM_119938.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables squalene monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables squalene monooxygenase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    squalene epoxidase 3
    NP_568033.1
    • squalene epoxidase 3 (SQE3); FUNCTIONS IN: squalene monooxygenase activity; INVOLVED IN: response to jasmonic acid stimulus, response to wounding, sterol biosynthetic process; LOCATED IN: endomembrane system, integral to membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Squalene epoxidase (InterPro:IPR013698), Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal (InterPro:IPR003953); BEST Arabidopsis thaliana protein match is: squalene epoxidase 2 (TAIR:AT2G22830.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17743738..17746697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119938.4 → NP_568033.1  squalene epoxidase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568033.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VYH2, Q9T064
      UniProtKB/TrEMBL
      A0A178UU38, A0A5S9XZX1, A0A654FWX8
      Conserved Domains (2) summary
      COG0654
      Location:69 → 432
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
      pfam08491
      Location:205 → 478
      SE; Squalene epoxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VYH2.1

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