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    Snhg14 small nucleolar RNA host gene 14 [ Mus musculus (house mouse) ]

    Gene ID: 52480, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Snhg14provided by MGI
    Official Full Name
    small nucleolar RNA host gene 14provided by MGI
    Primary source
    MGI:MGI:1289201
    See related
    AllianceGenome:MGI:1289201
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lncat; Pwcr1; Gm42386; Gm42387; Gm42388; Gm42389; Gm42390; Gm42391; Gm45921; Ube3a-ATS; D7Ertd715e; U-Ube3a-ATS; lincRNA-EC50; C230091D08Rik
    Summary
    This gene is located within the Prader-Willi critical region and produces a long, spliced, paternally-imprinted RNA that is thought to share a promoter and exons with the Snrpn (small nuclear ribonucleoprotein polypeptide N) and Snurf genes. This transcript serves as a host RNA for two small nucleolar RNA clusters, and also extends in antisense into the region of the ubiquitin protein ligase E3A gene (Ube3a). It is thought to regulate imprinted expression of Ube3a in the brain. This transcript undergoes extensive alternative splicing, and may initiate and terminate at multiple locations within a greater than 1 Mb genomic region. The full-length structure of all splice forms is not determined. [provided by RefSeq, Mar 2017]
    Expression
    Biased expression in whole brain E14.5 (RPKM 9.3), CNS E14 (RPKM 8.8) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snhg14 in Genome Data Viewer
    Location:
    7 B5; 7 34.04 cM
    Exon count:
    172
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (58922485..60099925, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (59272737..60450177, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18990 Neighboring gene predicted gene 9375 Neighboring gene STARR-seq mESC enhancer starr_18991 Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18992 Neighboring gene ubiquitin protein ligase E3A Neighboring gene predicted gene, 25499 Neighboring gene predicted gene, 57512 Neighboring gene predicted gene, 22496 Neighboring gene predicted gene, 25648 Neighboring gene predicted gene, 24306 Neighboring gene predicted gene, 25934 Neighboring gene predicted gene, 25156 Neighboring gene predicted gene, 26488 Neighboring gene predicted gene, 24220 Neighboring gene predicted gene, 24653 Neighboring gene predicted gene, 24969 Neighboring gene predicted gene, 25121 Neighboring gene predicted gene, 24417 Neighboring gene predicted gene, 24657 Neighboring gene predicted gene, 26230 Neighboring gene predicted gene, 23922 Neighboring gene predicted gene, 25314 Neighboring gene predicted gene, 26096 Neighboring gene predicted gene, 22996 Neighboring gene predicted gene, 26499 Neighboring gene predicted gene, 25646 Neighboring gene predicted gene, 26498 Neighboring gene predicted gene, 23660 Neighboring gene predicted gene, 23933 Neighboring gene predicted gene, 24862 Neighboring gene predicted gene, 24866 Neighboring gene predicted gene, 22348 Neighboring gene predicted gene, 26466 Neighboring gene predicted gene, 24799 Neighboring gene predicted gene, 24088 Neighboring gene predicted gene, 25463 Neighboring gene predicted gene, 25229 Neighboring gene predicted gene, 24528 Neighboring gene predicted gene, 23356 Neighboring gene predicted gene, 25449 Neighboring gene predicted gene, 24872 Neighboring gene predicted gene, 26337 Neighboring gene predicted gene, 23145 Neighboring gene predicted gene, 25988 Neighboring gene predicted gene, 25221 Neighboring gene predicted gene, 22130 Neighboring gene predicted gene, 26389 Neighboring gene predicted gene, 23471 Neighboring gene predicted gene, 25120 Neighboring gene predicted gene, 24418 Neighboring gene predicted gene, 23687 Neighboring gene predicted gene, 22393 Neighboring gene predicted gene, 24639 Neighboring gene predicted gene, 24566 Neighboring gene predicted gene, 22111 Neighboring gene predicted gene, 23076 Neighboring gene predicted gene, 25874 Neighboring gene predicted gene, 22510 Neighboring gene predicted gene, 25088 Neighboring gene predicted gene, 24027 Neighboring gene predicted gene, 22630 Neighboring gene predicted gene, 22524 Neighboring gene predicted gene, 25741 Neighboring gene predicted gene, 26059 Neighboring gene predicted gene, 25175 Neighboring gene predicted gene, 22511 Neighboring gene predicted gene, 25077 Neighboring gene predicted gene, 22834 Neighboring gene predicted gene, 24926 Neighboring gene predicted gene, 26200 Neighboring gene predicted gene, 22632 Neighboring gene predicted gene, 23254 Neighboring gene predicted gene, 26390 Neighboring gene predicted gene, 26366 Neighboring gene predicted gene, 26336 Neighboring gene predicted gene, 26283 Neighboring gene predicted gene, 25098 Neighboring gene predicted gene, 24702 Neighboring gene predicted gene, 26432 Neighboring gene predicted gene, 25462 Neighboring gene predicted gene, 24495 Neighboring gene predicted gene, 25523 Neighboring gene predicted gene, 22255 Neighboring gene predicted gene, 23449 Neighboring gene predicted gene, 23310 Neighboring gene predicted gene, 25461 Neighboring gene predicted gene, 24310 Neighboring gene predicted gene, 22909 Neighboring gene predicted gene, 25823 Neighboring gene predicted gene, 25647 Neighboring gene predicted gene, 22252 Neighboring gene predicted gene, 26392 Neighboring gene predicted gene, 24219 Neighboring gene predicted gene, 25230 Neighboring gene predicted gene, 22627 Neighboring gene predicted gene, 24585 Neighboring gene predicted gene, 23305 Neighboring gene predicted gene, 24206 Neighboring gene predicted gene, 25209 Neighboring gene predicted gene, 23682 Neighboring gene predicted gene, 25085 Neighboring gene predicted gene, 24654 Neighboring gene predicted gene, 26334 Neighboring gene predicted gene, 25742 Neighboring gene predicted gene, 25585 Neighboring gene predicted gene, 25840 Neighboring gene predicted gene, 25089 Neighboring gene predicted gene, 24040 Neighboring gene predicted gene, 22050 Neighboring gene predicted gene, 23286 Neighboring gene predicted gene, 24021 Neighboring gene predicted gene, 23618 Neighboring gene predicted gene, 24652 Neighboring gene predicted gene, 22274 Neighboring gene predicted gene, 23688 Neighboring gene predicted gene, 26467 Neighboring gene predicted gene, 24570 Neighboring gene predicted gene, 25194 Neighboring gene predicted gene, 22640 Neighboring gene predicted gene, 24952 Neighboring gene predicted gene, 25087 Neighboring gene predicted gene, 23944 Neighboring gene predicted gene, 22629 Neighboring gene predicted gene, 26374 Neighboring gene predicted gene, 26284 Neighboring gene predicted gene, 25452 Neighboring gene predicted gene, 25984 Neighboring gene predicted gene, 25146 Neighboring gene predicted gene, 24759 Neighboring gene predicted gene, 24100 Neighboring gene predicted gene, 22253 Neighboring gene predicted gene, 23575 Neighboring gene predicted gene, 25017 Neighboring gene predicted gene, 22391 Neighboring gene predicted gene, 22449 Neighboring gene predicted gene, 24137 Neighboring gene predicted gene, 22912 Neighboring gene predicted gene, 25710 Neighboring gene predicted gene, 26434 Neighboring gene predicted gene, 23560 Neighboring gene predicted gene, 25870 Neighboring gene predicted gene, 23862 Neighboring gene predicted gene, 26504 Neighboring gene predicted gene, 22285 Neighboring gene predicted gene, 22131 Neighboring gene predicted gene, 24153 Neighboring gene predicted gene, 26365 Neighboring gene predicted gene, 24609 Neighboring gene predicted gene, 24264 Neighboring gene predicted gene, 25155 Neighboring gene predicted gene, 25816 Neighboring gene predicted gene, 23141 Neighboring gene predicted gene, 23767 Neighboring gene predicted gene, 22584 Neighboring gene predicted gene, 22417 Neighboring gene imprinted gene in the Prader-Willi syndrome region Neighboring gene predicted gene, 26270 Neighboring gene predicted gene, 23089 Neighboring gene predicted gene, 24711 Neighboring gene predicted gene, 26188 Neighboring gene predicted gene, 23265 Neighboring gene predicted gene, 24518 Neighboring gene predicted gene, 25944 Neighboring gene predicted gene, 23047 Neighboring gene predicted gene, 23953 Neighboring gene predicted gene, 26332 Neighboring gene predicted gene, 26032 Neighboring gene predicted gene, 22863 Neighboring gene predicted gene, 22046 Neighboring gene predicted gene, 24618 Neighboring gene predicted gene, 24760 Neighboring gene predicted gene, 25350 Neighboring gene predicted gene, 26502 Neighboring gene predicted gene, 23313 Neighboring gene predicted gene, 25471 Neighboring gene small nucleolar RNA, C/D box 116-like 17 Neighboring gene predicted gene, 22776 Neighboring gene predicted gene, 23446 Neighboring gene small nucleolar RNA, C/D box 116-like 16 Neighboring gene small nucleolar RNA, C/D box 116-like 15 Neighboring gene small nucleolar RNA, C/D box 116-like 14 Neighboring gene predicted gene, 25210 Neighboring gene predicted gene, 22128 Neighboring gene small nucleolar RNA, C/D box 116-like 13 Neighboring gene predicted gene, 25074 Neighboring gene predicted gene, 22851 Neighboring gene predicted gene, 22631 Neighboring gene predicted gene, 25157 Neighboring gene predicted gene, 25474 Neighboring gene predicted gene, 22941 Neighboring gene predicted gene, 26246 Neighboring gene predicted gene, 22047 Neighboring gene predicted gene, 25597 Neighboring gene predicted gene, 26097 Neighboring gene small nucleolar RNA, C/D box 116-like 10 Neighboring gene small nucleolar RNA, C/D box 116-like 2 Neighboring gene small nucleolar RNA, C/D box 116-like 11 Neighboring gene predicted gene, 26201 Neighboring gene predicted gene, 22258 Neighboring gene small nucleolar RNA, C/D box 116-like 12 Neighboring gene predicted gene, 22812 Neighboring gene predicted gene, 23619 Neighboring gene small nucleolar RNA, C/D box 116-like 8 Neighboring gene small nucleolar RNA, C/D box 116-like 7 Neighboring gene small nucleolar RNA, C/D box 116-like 6 Neighboring gene small nucleolar RNA, C/D box 116-like 5 Neighboring gene small nucleolar RNA, C/D box 116-like 3 Neighboring gene small nucleolar RNA, C/D box 116-like 4 Neighboring gene small nucleolar RNA, C/D box 116-like 1 Neighboring gene small nucleolar RNA, C/D box 116-like 9 Neighboring gene predicted gene, 26433 Neighboring gene predicted gene, 25615 Neighboring gene predicted gene, 22373 Neighboring gene small nucleolar RNA, C/D box 107 Neighboring gene small nucleolar RNA, C/D box 64 Neighboring gene SNRPN upstream reading frame Neighboring gene small nuclear ribonucleoprotein N Neighboring gene pyruvate dehydrogenase complex, component X pseudogene Neighboring gene 1110014K08Rik pseudogene Neighboring gene predicted gene, 18129 Neighboring gene STARR-seq mESC enhancer starr_18994 Neighboring gene modulator of retrovirus infection homolog Neighboring gene STARR-seq mESC enhancer starr_18995 Neighboring gene sorbitol dehydrogenase pseudogene Neighboring gene G kinase anchoring protein 1 pseudogene Neighboring gene sorbitol dehydrogenase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic developmental regulation of the large non-coding RNA associated with the mouse 7C imprinted chromosomal region. Le Meur E, et al. Dev Biol, 2005 Oct 15. PMID 16126194
    2. Long Noncoding RNA SNHG14 Promotes Ischemic Brain Injury via Regulating miR-199b/AQP4 Axis. Zhang G, et al. Neurochem Res, 2021 May. PMID 33609254
    3. Highly parallel SNP genotyping reveals high-resolution landscape of mono-allelic Ube3a expression associated with locus-wide antisense transcription. Numata K, et al. Nucleic Acids Res, 2011 Apr. PMID 21131283, Free PMC Article
    4. Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader-Willi Syndrome Etiology. Ariyanfar S, et al. Genes (Basel), 2022 Dec 29. PMID 36672838, Free PMC Article
    5. CRISPR/Cas9 directed to the Ube3a antisense transcript improves Angelman syndrome phenotype in mice. Schmid RS, et al. J Clin Invest, 2021 Mar 1. PMID 33411694, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA SNHG14 silencing attenuates the progression of diabetic nephropathy via the miR-30e-5p/SOX4 axis.
      Title: LncRNA SNHG14 silencing attenuates the progression of diabetic nephropathy via the miR-30e-5p/SOX4 axis.
    2. LncRNA SNHG14 Served as a Biomarker of Depression Disorder Patients and Regulated Depression-Like Behaviors via MiR-200a-3p.
      Title: LncRNA SNHG14 Served as a Biomarker of Depression Disorder Patients and Regulated Depression-Like Behaviors via MiR-200a-3p.
    3. SNHG14 Elevates NFAT5 Expression Through Sequestering miR-375-3p to Promote MPP + -Induced Neuronal Apoptosis, Inflammation, and Oxidative Stress in Parkinson's Disease.
      Title: SNHG14 Elevates NFAT5 Expression Through Sequestering miR-375-3p to Promote MPP + -Induced Neuronal Apoptosis, Inflammation, and Oxidative Stress in Parkinson's Disease.
    4. LncRNA SNHG14 activates autophagy via regulating miR-493-5p/Mef2c axis to alleviate osteoporosis progression.
      Title: LncRNA SNHG14 activates autophagy via regulating miR-493-5p/Mef2c axis to alleviate osteoporosis progression.
    5. Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader-Willi Syndrome Etiology.
      Title: Analysis of SNHG14: A Long Non-Coding RNA Hosting SNORD116, Whose Loss Contributes to Prader-Willi Syndrome Etiology.
    6. Long Noncoding RNA SNHG14 Promotes Ischemic Brain Injury via Regulating miR-199b/AQP4 Axis.
      Title: Long Noncoding RNA SNHG14 Promotes Ischemic Brain Injury via Regulating miR-199b/AQP4 Axis.
    7. CRISPR/Cas9 directed to the Ube3a antisense transcript improves Angelman syndrome phenotype in mice.
      Title: CRISPR/Cas9 directed to the Ube3a antisense transcript improves Angelman syndrome phenotype in mice.
    8. SP1-induced SNHG14 aggravates hypertrophic response in in vitro model of cardiac hypertrophy via up-regulation of PCDH17.
      Title: SP1-induced SNHG14 aggravates hypertrophic response in in vitro model of cardiac hypertrophy via up-regulation of PCDH17.
    9. Dopaminergic neuron injury in Parkinson's disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ alpha-synuclein pathway.
      Title: Dopaminergic neuron injury in Parkinson's disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ α-synuclein pathway.
    10. SNHG14 increased the expression of PLA2G4A by inhibition of miR-145-5p, which resulted in the activation of microglia in cerebral infarction.
      Title: Long non-coding RNA SNHG14 promotes microglia activation by regulating miR-145-5p/PLA2G4A in cerebral infarction.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Other Names

    • Ube3a antisense transcript

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_146211.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC046145, AC130677, AC151574, AC167813, AC167971, AC168073, AC169674, AC171272, AC172750, AC221015

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      58922485..60099925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_015456.1: Suppressed sequence

      Description
      NR_015456.1: This RefSeq was removed because currently there is insufficient evidence that it represents a complete transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.